id
stringlengths
1
4
document_id
stringlengths
8
11
passages
list
entities
list
events
list
coreferences
list
relations
list
1192
9816035:1
[ { "id": "1193", "type": "sentence", "text": [ "Amonafide is a new imide derivative of naphthalic acid ." ], "offsets": [ [ 0, 56 ] ] } ]
[ { "id": "1194", "type": "intervention", "text": [ "Amonafide" ], "offsets": [ [ 0, 9 ] ], "normalized": [] } ]
[]
[]
[]
1195
23356250:10
[ { "id": "1196", "type": "sentence", "text": [ "Regular intake of lime juice may be of great therapeutic and nutritional relevance in children with SCA ." ], "offsets": [ [ 0, 105 ] ] } ]
[ { "id": "1197", "type": "intervention", "text": [ "lime juice" ], "offsets": [ [ 18, 28 ] ], "normalized": [] }, { "id": "1198", "type": "participant", "text": [ "children with SCA" ], "offsets": [ [ 86, 103 ] ], "normalized": [] } ]
[]
[]
[]
1199
7831628:9
[ { "id": "1200", "type": "sentence", "text": [ "Constant exhalation may therefore be a useful alternative to the breath holding technique for clinical measurement of TLCO ." ], "offsets": [ [ 0, 124 ] ] } ]
[ { "id": "1201", "type": "intervention", "text": [ "TLCO" ], "offsets": [ [ 118, 122 ] ], "normalized": [] }, { "id": "1202", "type": "outcome", "text": [ "clinical measurement of TLCO" ], "offsets": [ [ 94, 122 ] ], "normalized": [] } ]
[]
[]
[]
1203
24451919:9
[ { "id": "1204", "type": "sentence", "text": [ "Both patient groups shared decreased precuneus activation ." ], "offsets": [ [ 0, 59 ] ] } ]
[ { "id": "1205", "type": "outcome", "text": [ "precuneus activation" ], "offsets": [ [ 37, 57 ] ], "normalized": [] } ]
[]
[]
[]
1206
11317090:0
[ { "id": "1207", "type": "sentence", "text": [ "Economic evaluation of aquatic exercise for persons with osteoarthritis ." ], "offsets": [ [ 0, 73 ] ] } ]
[ { "id": "1208", "type": "intervention", "text": [ "aquatic exercise" ], "offsets": [ [ 23, 39 ] ], "normalized": [] }, { "id": "1209", "type": "outcome", "text": [ "Economic evaluation" ], "offsets": [ [ 0, 19 ] ], "normalized": [] }, { "id": "1210", "type": "participant", "text": [ "persons with osteoarthritis" ], "offsets": [ [ 44, 71 ] ], "normalized": [] } ]
[]
[]
[]
1211
7831628:5
[ { "id": "1212", "type": "sentence", "text": [ "Patients did not practise the exhalation manoeuvre prior to testing ." ], "offsets": [ [ 0, 69 ] ] } ]
[]
[]
[]
[]
1213
11891832:5
[ { "id": "1214", "type": "sentence", "text": [ "Serum creatine kinase activity decreased significantly in the methotrexate group ." ], "offsets": [ [ 0, 82 ] ] } ]
[ { "id": "1215", "type": "intervention", "text": [ "methotrexate" ], "offsets": [ [ 62, 74 ] ], "normalized": [] }, { "id": "1216", "type": "outcome", "text": [ "Serum creatine kinase activity" ], "offsets": [ [ 0, 30 ] ], "normalized": [] } ]
[]
[]
[]
1217
19802506:1
[ { "id": "1218", "type": "sentence", "text": [ "This study examined whether 24 months of weight training exercises enhanced the effectiveness of risedronate , calcium , and vitamin D in maintaining or improving bone mineral density ( BMD ) in 223 postmenopausal breast cancer survivors ." ], "offsets": [ [ 0, 239 ] ] } ]
[ { "id": "1219", "type": "intervention", "text": [ "weight training exercises" ], "offsets": [ [ 41, 66 ] ], "normalized": [] }, { "id": "1220", "type": "outcome", "text": [ "effectiveness" ], "offsets": [ [ 80, 93 ] ], "normalized": [] }, { "id": "1221", "type": "outcome", "text": [ "bone mineral density ( BMD )" ], "offsets": [ [ 163, 191 ] ], "normalized": [] }, { "id": "1222", "type": "participant", "text": [ "223 postmenopausal breast cancer survivors" ], "offsets": [ [ 195, 237 ] ], "normalized": [] } ]
[]
[]
[]
1223
23417625:3
[ { "id": "1224", "type": "sentence", "text": [ "To compare the effect of a Social Skills Training Group-based Program ( SST-GP ) and a Leisure Activities Group-based Program ( LA-GP ) on the perception of facial emotions and quality of life ( QoL ) in young people with HFA ." ], "offsets": [ [ 0, 227 ] ] } ]
[ { "id": "1225", "type": "intervention", "text": [ "Social Skills Training Group-based Program ( SST-GP )" ], "offsets": [ [ 27, 80 ] ], "normalized": [] }, { "id": "1226", "type": "intervention", "text": [ "Leisure Activities Group-based Program ( LA-GP )" ], "offsets": [ [ 87, 135 ] ], "normalized": [] }, { "id": "1227", "type": "outcome", "text": [ "perception of facial emotions and quality of life ( QoL )" ], "offsets": [ [ 143, 200 ] ], "normalized": [] }, { "id": "1228", "type": "participant", "text": [ "young people with HFA" ], "offsets": [ [ 204, 225 ] ], "normalized": [] } ]
[]
[]
[]
1229
21896676:2
[ { "id": "1230", "type": "sentence", "text": [ "To investigate whether a physiotherapy service to an EECU altered the rate of hospital admission , rate of re-presentation to the ED , visits to community healthcare practitioners , return to usual work/home/leisure activities and patient satisfaction ." ], "offsets": [ [ 0, 253 ] ] } ]
[ { "id": "1231", "type": "intervention", "text": [ "physiotherapy service" ], "offsets": [ [ 25, 46 ] ], "normalized": [] }, { "id": "1232", "type": "outcome", "text": [ "rate of hospital admission , rate of re-presentation to the ED , visits to community healthcare practitioners , return to usual work/home/leisure activities and patient satisfaction" ], "offsets": [ [ 70, 251 ] ], "normalized": [] } ]
[]
[]
[]
1233
21106663:6
[ { "id": "1234", "type": "sentence", "text": [ "Depressive symptoms and biochemically verified abstinence were assessed 1 week prior to and 2 , 8 , 16 , and 26 weeks after quit date ." ], "offsets": [ [ 0, 135 ] ] } ]
[ { "id": "1235", "type": "outcome", "text": [ "Depressive symptoms and biochemically verified abstinence" ], "offsets": [ [ 0, 57 ] ], "normalized": [] } ]
[]
[]
[]
1236
22865017:16
[ { "id": "1237", "type": "sentence", "text": [ "Results suggest the need for careful examination of the way that collaborative care models are implemented for treating PTSD , and for additional supports to encourage primary care providers to manage PTSD ." ], "offsets": [ [ 0, 207 ] ] } ]
[ { "id": "1238", "type": "intervention", "text": [ "collaborative care" ], "offsets": [ [ 65, 83 ] ], "normalized": [] } ]
[]
[]
[]
1239
11737955:4
[ { "id": "1240", "type": "sentence", "text": [ "Antipyrine was used as marker for oxidative stress ." ], "offsets": [ [ 0, 52 ] ] } ]
[ { "id": "1241", "type": "intervention", "text": [ "Antipyrine" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "1242", "type": "outcome", "text": [ "Antipyrine" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "1243", "type": "outcome", "text": [ "oxidative stress" ], "offsets": [ [ 34, 50 ] ], "normalized": [] } ]
[]
[]
[]
1244
11891832:3
[ { "id": "1245", "type": "sentence", "text": [ "Quantitative muscle strength testing sum scores declined in both treatment groups , -0.2 % for methotrexate and -3.4 % for placebo ( 95 % confidence interval = -2.5 % to +9.1 % for difference ) ." ], "offsets": [ [ 0, 195 ] ] } ]
[ { "id": "1246", "type": "intervention", "text": [ "methotrexate" ], "offsets": [ [ 95, 107 ] ], "normalized": [] }, { "id": "1247", "type": "intervention", "text": [ "placebo" ], "offsets": [ [ 123, 130 ] ], "normalized": [] }, { "id": "1248", "type": "outcome", "text": [ "Quantitative muscle strength testing sum scores" ], "offsets": [ [ 0, 47 ] ], "normalized": [] } ]
[]
[]
[]
1249
11229858:2
[ { "id": "1250", "type": "sentence", "text": [ "Antipyretic treatment had no effect on fever clearance and therefore should be used cautiously in the treatment of malaria ." ], "offsets": [ [ 0, 124 ] ] } ]
[ { "id": "1251", "type": "intervention", "text": [ "Antipyretic" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "1252", "type": "outcome", "text": [ "fever clearance" ], "offsets": [ [ 39, 54 ] ], "normalized": [] }, { "id": "1253", "type": "participant", "text": [ "malaria" ], "offsets": [ [ 115, 122 ] ], "normalized": [] } ]
[]
[]
[]
1254
11317090:1
[ { "id": "1255", "type": "sentence", "text": [ "To estimate cost and outcomes of the Arthritis Foundation aquatic exercise classes from the societal perspective ." ], "offsets": [ [ 0, 114 ] ] } ]
[ { "id": "1256", "type": "intervention", "text": [ "aquatic exercise classes" ], "offsets": [ [ 58, 82 ] ], "normalized": [] }, { "id": "1257", "type": "outcome", "text": [ "cost and outcomes" ], "offsets": [ [ 12, 29 ] ], "normalized": [] } ]
[]
[]
[]
1258
18229990:8
[ { "id": "1259", "type": "sentence", "text": [ "These findings suggest clinically significant benefits of actively treating JA and SP skills in young children with autism ." ], "offsets": [ [ 0, 124 ] ] } ]
[ { "id": "1260", "type": "intervention", "text": [ "JA" ], "offsets": [ [ 76, 78 ] ], "normalized": [] }, { "id": "1261", "type": "intervention", "text": [ "SP" ], "offsets": [ [ 83, 85 ] ], "normalized": [] }, { "id": "1262", "type": "participant", "text": [ "young children with autism" ], "offsets": [ [ 96, 122 ] ], "normalized": [] } ]
[]
[]
[]
1263
12595499:0
[ { "id": "1264", "type": "sentence", "text": [ "Development of renal disease in people at high cardiovascular risk : results of the HOPE randomized study ." ], "offsets": [ [ 0, 107 ] ] } ]
[ { "id": "1265", "type": "outcome", "text": [ "Development of renal disease" ], "offsets": [ [ 0, 28 ] ], "normalized": [] }, { "id": "1266", "type": "participant", "text": [ "in people at high cardiovascular risk" ], "offsets": [ [ 29, 66 ] ], "normalized": [] } ]
[]
[]
[]
1267
24451919:3
[ { "id": "1268", "type": "sentence", "text": [ "Thus , this study investigates shared and disorder-specific brain dysfunctions in these 2 disorders during reward reversal , and the acute effects of an SSRI on these ." ], "offsets": [ [ 0, 168 ] ] } ]
[ { "id": "1269", "type": "outcome", "text": [ "shared and disorder-specific brain dysfunctions" ], "offsets": [ [ 31, 78 ] ], "normalized": [] } ]
[]
[]
[]
1270
11750293:6
[ { "id": "1271", "type": "sentence", "text": [ "These were initial level of depression , disability , pain , beliefs about the consequences of arthritis and coping strategies ." ], "offsets": [ [ 0, 128 ] ] } ]
[ { "id": "1272", "type": "outcome", "text": [ "initial level of depression , disability , pain , beliefs about the consequences of arthritis and coping strategies" ], "offsets": [ [ 11, 126 ] ], "normalized": [] } ]
[]
[]
[]
1273
23021296:6
[ { "id": "1274", "type": "sentence", "text": [ "Patients in the experimental group received a brief note in which they were explicitly asked to increase both their physical activity level and time of sun exposure , while control group patients did not receive these explicit recommendations ." ], "offsets": [ [ 0, 244 ] ] } ]
[ { "id": "1275", "type": "intervention", "text": [ "physical activity" ], "offsets": [ [ 116, 133 ] ], "normalized": [] }, { "id": "1276", "type": "intervention", "text": [ "sun exposure" ], "offsets": [ [ 152, 164 ] ], "normalized": [] }, { "id": "1277", "type": "intervention", "text": [ "control" ], "offsets": [ [ 173, 180 ] ], "normalized": [] }, { "id": "1278", "type": "intervention", "text": [ "did not receive these explicit recommendations" ], "offsets": [ [ 196, 242 ] ], "normalized": [] }, { "id": "1279", "type": "outcome", "text": [ "physical activity level" ], "offsets": [ [ 116, 139 ] ], "normalized": [] }, { "id": "1280", "type": "outcome", "text": [ "time of sun exposure" ], "offsets": [ [ 144, 164 ] ], "normalized": [] } ]
[]
[]
[]
1281
12960652:4
[ { "id": "1282", "type": "sentence", "text": [ "At present no study of gastric dysrhythmia , measured with epigastric impedance , has been presented , and the purpose of the present study was to investigate gastric rhythms by means of impedance gastrography in control infants , compared to infants with different gastrointestinal diseases , before and after treatment of their disease ." ], "offsets": [ [ 0, 339 ] ] } ]
[ { "id": "1283", "type": "intervention", "text": [ "epigastric impedance" ], "offsets": [ [ 59, 79 ] ], "normalized": [] }, { "id": "1284", "type": "outcome", "text": [ "gastric dysrhythmia" ], "offsets": [ [ 23, 42 ] ], "normalized": [] }, { "id": "1285", "type": "outcome", "text": [ "epigastric impedance" ], "offsets": [ [ 59, 79 ] ], "normalized": [] }, { "id": "1286", "type": "outcome", "text": [ "gastric rhythms" ], "offsets": [ [ 159, 174 ] ], "normalized": [] }, { "id": "1287", "type": "outcome", "text": [ "impedance gastrography" ], "offsets": [ [ 187, 209 ] ], "normalized": [] }, { "id": "1288", "type": "participant", "text": [ "control infants , compared to infants with different gastrointestinal diseases , before and after treatment of their disease" ], "offsets": [ [ 213, 337 ] ], "normalized": [] } ]
[]
[]
[]
1289
11737955:1
[ { "id": "1290", "type": "sentence", "text": [ "The effects of 12 weeks of antioxidant supplementation on exercise-induced oxidative stress were investigated in older adults ( 60 ( SE 1 ) years ; BMI 26 ( SE 1 ) kg/m ( 2 ) ) ." ], "offsets": [ [ 0, 178 ] ] } ]
[ { "id": "1291", "type": "intervention", "text": [ "antioxidant supplementation" ], "offsets": [ [ 27, 54 ] ], "normalized": [] }, { "id": "1292", "type": "outcome", "text": [ "exercise-induced oxidative stress" ], "offsets": [ [ 58, 91 ] ], "normalized": [] }, { "id": "1293", "type": "participant", "text": [ "older adults ( 60 ( SE 1 ) years ; BMI 26 ( SE 1 ) kg/m ( 2 ) )" ], "offsets": [ [ 113, 176 ] ], "normalized": [] } ]
[]
[]
[]
1294
11750293:7
[ { "id": "1295", "type": "sentence", "text": [ "The results confirm the importance of psychological factors in early RA and their relative independence from physical findings ." ], "offsets": [ [ 0, 128 ] ] } ]
[]
[]
[]
[]
1296
11317090:5
[ { "id": "1297", "type": "sentence", "text": [ "Recruited 249 adults from Washington State aged 55 to 75 with a doctor-confirmed diagnosis of osteoarthritis to participate in aquatic classes ." ], "offsets": [ [ 0, 144 ] ] } ]
[ { "id": "1298", "type": "intervention", "text": [ "aquatic classes" ], "offsets": [ [ 127, 142 ] ], "normalized": [] }, { "id": "1299", "type": "participant", "text": [ "249 adults from Washington State aged 55 to 75 with a doctor-confirmed diagnosis of osteoarthritis to participate in aquatic classes" ], "offsets": [ [ 10, 142 ] ], "normalized": [] } ]
[]
[]
[]
1300
21896676:4
[ { "id": "1301", "type": "sentence", "text": [ "The sample comprised 186 patients ( mean age 70 years , 123 ( 66 % ) female patients , 130 ( 70 % ) trauma ) who were referred for physiotherapy assessment/intervention ." ], "offsets": [ [ 0, 170 ] ] } ]
[ { "id": "1302", "type": "intervention", "text": [ "physiotherapy assessment/intervention" ], "offsets": [ [ 131, 168 ] ], "normalized": [] }, { "id": "1303", "type": "participant", "text": [ "The sample comprised 186 patients ( mean age 70 years , 123 ( 66 % ) female patients , 130 ( 70 % ) trauma ) who were referred for physiotherapy assessment/intervention" ], "offsets": [ [ 0, 168 ] ], "normalized": [] } ]
[]
[]
[]
1304
23849147:3
[ { "id": "1305", "type": "sentence", "text": [ "The trial design is compared to a trial without adaptive randomization and produces an efficient trial in which a higher proportion of patients are likely to be randomized to the most effective treatment arm while generally using fewer total patients and offers higher power than an analogous trial with fixed randomization when identifying a superior treatment ." ], "offsets": [ [ 0, 363 ] ] } ]
[ { "id": "1306", "type": "intervention", "text": [ "trial without adaptive randomization" ], "offsets": [ [ 34, 70 ] ], "normalized": [] }, { "id": "1307", "type": "outcome", "text": [ "proportion of patients" ], "offsets": [ [ 121, 143 ] ], "normalized": [] }, { "id": "1308", "type": "outcome", "text": [ "total patients" ], "offsets": [ [ 236, 250 ] ], "normalized": [] } ]
[]
[]
[]
1309
23417625:11
[ { "id": "1310", "type": "sentence", "text": [ "Data justify replication using larger samples ." ], "offsets": [ [ 0, 47 ] ] } ]
[]
[]
[]
[]
1311
19802506:4
[ { "id": "1312", "type": "sentence", "text": [ "Postmenopausal BCS ( 223 ) were randomly assigned to exercise plus medication or medication only groups ." ], "offsets": [ [ 0, 105 ] ] } ]
[ { "id": "1313", "type": "intervention", "text": [ "exercise plus medication" ], "offsets": [ [ 53, 77 ] ], "normalized": [] }, { "id": "1314", "type": "intervention", "text": [ "medication" ], "offsets": [ [ 67, 77 ] ], "normalized": [] }, { "id": "1315", "type": "participant", "text": [ "Postmenopausal BCS ( 223 )" ], "offsets": [ [ 0, 26 ] ], "normalized": [] } ]
[]
[]
[]
1316
6421395:0
[ { "id": "1317", "type": "sentence", "text": [ "Effects of mild physical exercise on serum lipoproteins and metabolites of arachidonic acid : a controlled randomised trial in middle aged men ." ], "offsets": [ [ 0, 144 ] ] } ]
[ { "id": "1318", "type": "intervention", "text": [ "mild physical exercise" ], "offsets": [ [ 11, 33 ] ], "normalized": [] }, { "id": "1319", "type": "outcome", "text": [ "serum lipoproteins and metabolites of arachidonic acid" ], "offsets": [ [ 37, 91 ] ], "normalized": [] }, { "id": "1320", "type": "participant", "text": [ "middle aged men" ], "offsets": [ [ 127, 142 ] ], "normalized": [] } ]
[]
[]
[]
1321
24451919:1
[ { "id": "1322", "type": "sentence", "text": [ "Attention deficit hyperactivity disorder ( ADHD ) and autism spectrum disorder ( ASD ) share brain function abnormalities during cognitive flexibility ." ], "offsets": [ [ 0, 152 ] ] } ]
[ { "id": "1323", "type": "participant", "text": [ "Attention deficit hyperactivity disorder ( ADHD ) and autism spectrum disorder ( ASD )" ], "offsets": [ [ 0, 86 ] ], "normalized": [] } ]
[]
[]
[]
1324
24726342:6
[ { "id": "1325", "type": "sentence", "text": [ "ΔsRAW correlated with changes of intrathoracic gas volume ( ΔITGV ) ( r=0.61 ; p < 0.001 ) , residual volume ( ΔRV ) ( r=0.60 ; p < 0.001 ) , ΔFVC ( r=0.44 ; p=0.001 ) , and ΔVAS ( r=0.73 ; p < 0.001 ) , while ΔFEV1 correlated only with ΔFVC ( r=0.34 ; p=0.008 ) ." ], "offsets": [ [ 0, 264 ] ] } ]
[ { "id": "1326", "type": "outcome", "text": [ "intrathoracic gas volume ( ΔITGV )" ], "offsets": [ [ 33, 67 ] ], "normalized": [] }, { "id": "1327", "type": "outcome", "text": [ "residual volume ( ΔRV )" ], "offsets": [ [ 93, 116 ] ], "normalized": [] }, { "id": "1328", "type": "outcome", "text": [ "ΔFVC" ], "offsets": [ [ 142, 146 ] ], "normalized": [] }, { "id": "1329", "type": "outcome", "text": [ "ΔVAS" ], "offsets": [ [ 174, 178 ] ], "normalized": [] }, { "id": "1330", "type": "outcome", "text": [ "ΔFEV1" ], "offsets": [ [ 210, 215 ] ], "normalized": [] }, { "id": "1331", "type": "outcome", "text": [ "ΔFVC" ], "offsets": [ [ 142, 146 ] ], "normalized": [] } ]
[]
[]
[]
1332
21896676:6
[ { "id": "1333", "type": "sentence", "text": [ "All participants received medical/nursing care as required ." ], "offsets": [ [ 0, 60 ] ] } ]
[]
[]
[]
[]
1334
20560622:6
[ { "id": "1335", "type": "sentence", "text": [ "The in vitro assay showed similar solubility after the in vitro digestion and similar transport across Caco-2 cells ." ], "offsets": [ [ 0, 117 ] ] } ]
[ { "id": "1336", "type": "outcome", "text": [ "solubility" ], "offsets": [ [ 34, 44 ] ], "normalized": [] } ]
[]
[]
[]
1337
19802506:8
[ { "id": "1338", "type": "sentence", "text": [ "Additional changes in BMD and bone turnover with exercise were not significant ." ], "offsets": [ [ 0, 80 ] ] } ]
[ { "id": "1339", "type": "intervention", "text": [ "exercise" ], "offsets": [ [ 49, 57 ] ], "normalized": [] }, { "id": "1340", "type": "outcome", "text": [ "changes in BMD and bone turnover" ], "offsets": [ [ 11, 43 ] ], "normalized": [] } ]
[]
[]
[]
1341
22865017:1
[ { "id": "1342", "type": "sentence", "text": [ "Although collaborative care is effective for treating depression and other mental disorders in primary care , there have been no randomized trials of collaborative care specifically for patients with Posttraumatic stress disorder ( PTSD ) ." ], "offsets": [ [ 0, 240 ] ] } ]
[ { "id": "1343", "type": "intervention", "text": [ "collaborative care" ], "offsets": [ [ 9, 27 ] ], "normalized": [] }, { "id": "1344", "type": "participant", "text": [ "patients with Posttraumatic stress disorder ( PTSD )" ], "offsets": [ [ 186, 238 ] ], "normalized": [] } ]
[]
[]
[]
1345
9816035:0
[ { "id": "1346", "type": "sentence", "text": [ "Amonafide : An active agent in the treatment of previously untreated advanced breast cancer -- a cancer and leukemia group B study ( CALGB 8642 ) ." ], "offsets": [ [ 0, 147 ] ] } ]
[ { "id": "1347", "type": "intervention", "text": [ "Amonafide" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "1348", "type": "participant", "text": [ "previously untreated advanced breast cancer" ], "offsets": [ [ 48, 91 ] ], "normalized": [] } ]
[]
[]
[]
1349
23356250:9
[ { "id": "1350", "type": "sentence", "text": [ "Treatment with lime did not cause any significant side-effect ." ], "offsets": [ [ 0, 63 ] ] } ]
[ { "id": "1351", "type": "intervention", "text": [ "lime" ], "offsets": [ [ 15, 19 ] ], "normalized": [] }, { "id": "1352", "type": "outcome", "text": [ "significant side-effect" ], "offsets": [ [ 38, 61 ] ], "normalized": [] } ]
[]
[]
[]
1353
23417625:2
[ { "id": "1354", "type": "sentence", "text": [ "Although an increasing number of group-based programs for the improvement of social skills have been described , randomized controlled trials are needed to evaluate their efficacy ." ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "1355", "type": "outcome", "text": [ "social skills" ], "offsets": [ [ 77, 90 ] ], "normalized": [] }, { "id": "1356", "type": "outcome", "text": [ "efficacy" ], "offsets": [ [ 171, 179 ] ], "normalized": [] } ]
[]
[]
[]
1357
11750293:2
[ { "id": "1358", "type": "sentence", "text": [ "Twenty-two patients with a history of recently diagnosed RA of less than 2 years were assessed on a variety of clinical outcome and process measures on six assessment occasions over a 21-month period ." ], "offsets": [ [ 0, 201 ] ] } ]
[ { "id": "1359", "type": "outcome", "text": [ "clinical outcome and process measures" ], "offsets": [ [ 111, 148 ] ], "normalized": [] }, { "id": "1360", "type": "participant", "text": [ "Twenty-two patients with a history of recently diagnosed RA of less than 2 years" ], "offsets": [ [ 0, 80 ] ], "normalized": [] } ]
[]
[]
[]
1361
20560622:10
[ { "id": "1362", "type": "sentence", "text": [ "As calcium acquired during adolescence is essential to maximize peak bone mass and to prevent osteoporosis , possible long-term effects of excessive MRP intake during this period warrant attention ." ], "offsets": [ [ 0, 198 ] ] } ]
[ { "id": "1363", "type": "intervention", "text": [ "MRP" ], "offsets": [ [ 149, 152 ] ], "normalized": [] } ]
[]
[]
[]
1364
12576806:9
[ { "id": "1365", "type": "sentence", "text": [ "The 2 groups were comparable in terms of age , sex , symptoms and ipsilateral glomerular filtration rate ." ], "offsets": [ [ 0, 106 ] ] } ]
[ { "id": "1366", "type": "outcome", "text": [ "symptoms and ipsilateral glomerular filtration rate" ], "offsets": [ [ 53, 104 ] ], "normalized": [] } ]
[]
[]
[]
1367
11317090:6
[ { "id": "1368", "type": "sentence", "text": [ "The Quality of Well-Being Scale ( QWB ) and Current Health Desirability Rating ( CHDR ) were used for economic evaluation , supplemented by the arthritis-specific Health Assessment Questionnaire ( HAQ ) , Center for Epidemiologic Studies-Depression Scale ( CES-D ) , and Perceived Quality of Life Scale ( PQOL ) collected at baseline and postclass ." ], "offsets": [ [ 0, 349 ] ] } ]
[ { "id": "1369", "type": "outcome", "text": [ "Quality of Well-Being Scale ( QWB )" ], "offsets": [ [ 4, 39 ] ], "normalized": [] }, { "id": "1370", "type": "outcome", "text": [ "Current Health Desirability Rating ( CHDR )" ], "offsets": [ [ 44, 87 ] ], "normalized": [] }, { "id": "1371", "type": "outcome", "text": [ "economic evaluation" ], "offsets": [ [ 102, 121 ] ], "normalized": [] }, { "id": "1372", "type": "outcome", "text": [ "arthritis-specific Health Assessment Questionnaire ( HAQ )" ], "offsets": [ [ 144, 202 ] ], "normalized": [] }, { "id": "1373", "type": "outcome", "text": [ "Center for Epidemiologic Studies-Depression Scale ( CES-D )" ], "offsets": [ [ 205, 264 ] ], "normalized": [] }, { "id": "1374", "type": "outcome", "text": [ "Perceived Quality of Life Scale ( PQOL )" ], "offsets": [ [ 271, 311 ] ], "normalized": [] } ]
[]
[]
[]
1375
16505427:8
[ { "id": "1376", "type": "sentence", "text": [ "Patients in the 40K arm had a higher global quality of life ( QOL ) at baseline for unclear reasons , whereas patients in the 120K arm had a greater global QOL improvement during the study , so end-of-study QOL was equivalent ." ], "offsets": [ [ 0, 227 ] ] } ]
[ { "id": "1377", "type": "outcome", "text": [ "global quality of life ( QOL )" ], "offsets": [ [ 37, 67 ] ], "normalized": [] }, { "id": "1378", "type": "outcome", "text": [ "global QOL" ], "offsets": [ [ 149, 159 ] ], "normalized": [] }, { "id": "1379", "type": "outcome", "text": [ "QOL" ], "offsets": [ [ 62, 65 ] ], "normalized": [] } ]
[]
[]
[]
1380
2224060:5
[ { "id": "1381", "type": "sentence", "text": [ "Though this prolongation of remission was not significant in the bestatin group compared to the control group in the 15-49 yr age group , in the 50-65 yr age group it was significantly longer ." ], "offsets": [ [ 0, 193 ] ] } ]
[ { "id": "1382", "type": "intervention", "text": [ "bestatin" ], "offsets": [ [ 65, 73 ] ], "normalized": [] }, { "id": "1383", "type": "outcome", "text": [ "prolongation of remission" ], "offsets": [ [ 12, 37 ] ], "normalized": [] } ]
[]
[]
[]
1384
21106663:11
[ { "id": "1385", "type": "sentence", "text": [ "Efforts to promote smoking cessation should highlight that individuals are likely to feel more rather than less psychologically healthy when they successfully quit smoking ." ], "offsets": [ [ 0, 173 ] ] } ]
[]
[]
[]
[]
1386
2224060:2
[ { "id": "1387", "type": "sentence", "text": [ "A cooperative randomized controlled study of bestatin immunotherapy in combination with remission maintenance chemotherapy for adult acute nonlymphocytic leukemia ( ANLL ) was performed ." ], "offsets": [ [ 0, 187 ] ] } ]
[ { "id": "1388", "type": "intervention", "text": [ "bestatin" ], "offsets": [ [ 45, 53 ] ], "normalized": [] }, { "id": "1389", "type": "participant", "text": [ "adult acute nonlymphocytic leukemia ( ANLL )" ], "offsets": [ [ 127, 171 ] ], "normalized": [] } ]
[]
[]
[]
1390
20618920:1
[ { "id": "1391", "type": "sentence", "text": [ "In recent years some studies have been published supporting the efficacy of light exposure , physical activity , sleep control and a Mediterranean diet pattern on the improvement or prevention of depression ." ], "offsets": [ [ 0, 208 ] ] } ]
[ { "id": "1392", "type": "outcome", "text": [ "efficacy" ], "offsets": [ [ 64, 72 ] ], "normalized": [] } ]
[]
[]
[]
1393
23849147:4
[ { "id": "1394", "type": "sentence", "text": [ "When one treatment is superior to the other two , the trial design provides better patient care , higher power , and a lower expected sample size ." ], "offsets": [ [ 0, 147 ] ] } ]
[ { "id": "1395", "type": "outcome", "text": [ "patient care" ], "offsets": [ [ 83, 95 ] ], "normalized": [] }, { "id": "1396", "type": "outcome", "text": [ "power" ], "offsets": [ [ 105, 110 ] ], "normalized": [] }, { "id": "1397", "type": "outcome", "text": [ "expected sample size" ], "offsets": [ [ 125, 145 ] ], "normalized": [] } ]
[]
[]
[]
1398
11750293:0
[ { "id": "1399", "type": "sentence", "text": [ "The course of depression in recent onset rheumatoid arthritis : the predictive role of disability , illness perceptions , pain and coping ." ], "offsets": [ [ 0, 139 ] ] } ]
[ { "id": "1400", "type": "outcome", "text": [ "role" ], "offsets": [ [ 79, 83 ] ], "normalized": [] }, { "id": "1401", "type": "outcome", "text": [ "disability , illness perceptions , pain and coping" ], "offsets": [ [ 87, 137 ] ], "normalized": [] }, { "id": "1402", "type": "participant", "text": [ "recent onset rheumatoid arthritis" ], "offsets": [ [ 28, 61 ] ], "normalized": [] } ]
[]
[]
[]
1403
12960652:12
[ { "id": "1404", "type": "sentence", "text": [ "The origin of the gastric phasic activity patterns is unknown , but they may be related to electrical control activity ." ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "1405", "type": "outcome", "text": [ "gastric phasic activity patterns" ], "offsets": [ [ 18, 50 ] ], "normalized": [] } ]
[]
[]
[]
1406
23103798:11
[ { "id": "1407", "type": "sentence", "text": [ "In contrast , the number of wet nights and urodynamic parameters did not change significantly in group 2 ." ], "offsets": [ [ 0, 106 ] ] } ]
[ { "id": "1408", "type": "outcome", "text": [ "number of wet nights and urodynamic parameters" ], "offsets": [ [ 18, 64 ] ], "normalized": [] } ]
[]
[]
[]
1409
11737955:9
[ { "id": "1410", "type": "sentence", "text": [ "In addition , supplementation did not affect the exercise-induced increase in thiobarbituric acid reactive substances in plasma ." ], "offsets": [ [ 0, 129 ] ] } ]
[ { "id": "1411", "type": "outcome", "text": [ "thiobarbituric acid reactive substances in plasma" ], "offsets": [ [ 78, 127 ] ], "normalized": [] } ]
[]
[]
[]
1412
7853069:7
[ { "id": "1413", "type": "sentence", "text": [ "Patient outcomes were measured as changes in global anxiety scores , functioning and well-being , and patients ' reports of global improvements ." ], "offsets": [ [ 0, 145 ] ] } ]
[ { "id": "1414", "type": "outcome", "text": [ "Patient outcomes" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "1415", "type": "outcome", "text": [ "global anxiety scores , functioning and well-being ," ], "offsets": [ [ 45, 97 ] ], "normalized": [] }, { "id": "1416", "type": "outcome", "text": [ "patients ' reports of global improvements" ], "offsets": [ [ 102, 143 ] ], "normalized": [] } ]
[]
[]
[]
1417
20560622:1
[ { "id": "1418", "type": "sentence", "text": [ "Assays in male adolescents and in Caco-2 cells ." ], "offsets": [ [ 0, 48 ] ] } ]
[ { "id": "1419", "type": "participant", "text": [ "male adolescents" ], "offsets": [ [ 10, 26 ] ], "normalized": [] } ]
[]
[]
[]
1420
23356250:7
[ { "id": "1421", "type": "sentence", "text": [ "The mean hematocrit of the subjects ( 26.23±2.03 % ) at the end of the study was also higher , p < 0.001 ." ], "offsets": [ [ 0, 106 ] ] } ]
[ { "id": "1422", "type": "outcome", "text": [ "mean hematocrit" ], "offsets": [ [ 4, 19 ] ], "normalized": [] } ]
[]
[]
[]
1423
20618920:3
[ { "id": "1424", "type": "sentence", "text": [ "Multicenter , randomized , controlled , two arm-parallel , clinical trial ." ], "offsets": [ [ 0, 75 ] ] } ]
[]
[]
[]
[]
1425
23103798:2
[ { "id": "1426", "type": "sentence", "text": [ "We randomly assigned 28 patients with refractory monosymptomatic nocturnal enuresis to 2 equal groups ." ], "offsets": [ [ 0, 103 ] ] } ]
[ { "id": "1427", "type": "participant", "text": [ "28 patients with refractory monosymptomatic nocturnal enuresis" ], "offsets": [ [ 21, 83 ] ], "normalized": [] } ]
[]
[]
[]
1428
18845996:7
[ { "id": "1429", "type": "sentence", "text": [ "Using backward elimination , we derived a risk scoring algorithm ( range 0-63 ) from the final reduced model ." ], "offsets": [ [ 0, 110 ] ] } ]
[ { "id": "1430", "type": "outcome", "text": [ "risk scoring algorithm" ], "offsets": [ [ 42, 64 ] ], "normalized": [] } ]
[]
[]
[]
1431
18845996:5
[ { "id": "1432", "type": "sentence", "text": [ "Patient and hematologic factors potentially associated with NC were evaluated ." ], "offsets": [ [ 0, 79 ] ] } ]
[ { "id": "1433", "type": "outcome", "text": [ "Patient and hematologic factors potentially associated with NC" ], "offsets": [ [ 0, 62 ] ], "normalized": [] } ]
[]
[]
[]
1434
11891832:6
[ { "id": "1435", "type": "sentence", "text": [ "We conclude that oral methotrexate did not slow down progression of muscle weakness but decreased serum creatine kinase activity ." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "1436", "type": "intervention", "text": [ "methotrexate" ], "offsets": [ [ 22, 34 ] ], "normalized": [] }, { "id": "1437", "type": "outcome", "text": [ "progression of muscle weakness" ], "offsets": [ [ 53, 83 ] ], "normalized": [] }, { "id": "1438", "type": "outcome", "text": [ "serum creatine kinase activity" ], "offsets": [ [ 98, 128 ] ], "normalized": [] } ]
[]
[]
[]
1439
22865017:5
[ { "id": "1440", "type": "sentence", "text": [ "Blinded assessors collected data at baseline and 3-month and 6-month follow-up ." ], "offsets": [ [ 0, 80 ] ] } ]
[]
[]
[]
[]
1441
18845996:2
[ { "id": "1442", "type": "sentence", "text": [ "Data analyzed was from a phase III , randomized clinical trial of DOX ( 60 mg/m ( 2 ) every 3 weeks ) or PLD ( 50 mg/m ( 2 ) every 4 weeks ) for the first line therapy for MBC ( n = 509 ) ( O'Brien et al , Ann Oncol ." ], "offsets": [ [ 0, 217 ] ] } ]
[ { "id": "1443", "type": "intervention", "text": [ "DOX" ], "offsets": [ [ 66, 69 ] ], "normalized": [] }, { "id": "1444", "type": "intervention", "text": [ "PLD" ], "offsets": [ [ 105, 108 ] ], "normalized": [] }, { "id": "1445", "type": "participant", "text": [ "MBC ( n = 509 )" ], "offsets": [ [ 172, 187 ] ], "normalized": [] } ]
[]
[]
[]
1446
11495215:7
[ { "id": "1447", "type": "sentence", "text": [ "Heart rate , blood pressure , and lipid measures were taken at rest , during a videotaped speech task , and during recovery from the task ." ], "offsets": [ [ 0, 139 ] ] } ]
[ { "id": "1448", "type": "outcome", "text": [ "Heart rate , blood pressure , and lipid measures" ], "offsets": [ [ 0, 48 ] ], "normalized": [] } ]
[]
[]
[]
1449
23356250:6
[ { "id": "1450", "type": "sentence", "text": [ "Also , fewer subjects than the controls had significant painful episodes ( 50.0 % versus 92.7 % ) ; febrile illness ( 46.6 % versus 87.3 % ) and admission rate ( 3.4 % versus 34.5 % ) ( p < 0.001 ) ." ], "offsets": [ [ 0, 199 ] ] } ]
[ { "id": "1451", "type": "outcome", "text": [ "significant painful episodes" ], "offsets": [ [ 44, 72 ] ], "normalized": [] }, { "id": "1452", "type": "outcome", "text": [ "febrile illness" ], "offsets": [ [ 100, 115 ] ], "normalized": [] }, { "id": "1453", "type": "outcome", "text": [ "admission rate" ], "offsets": [ [ 145, 159 ] ], "normalized": [] } ]
[]
[]
[]
1454
18229990:7
[ { "id": "1455", "type": "sentence", "text": [ "For children beginning treatment with the lowest language levels , the JA intervention improved language outcome significantly more than did the SP or control interventions ." ], "offsets": [ [ 0, 174 ] ] } ]
[ { "id": "1456", "type": "intervention", "text": [ "JA" ], "offsets": [ [ 71, 73 ] ], "normalized": [] }, { "id": "1457", "type": "intervention", "text": [ "SP" ], "offsets": [ [ 145, 147 ] ], "normalized": [] }, { "id": "1458", "type": "outcome", "text": [ "language outcome" ], "offsets": [ [ 96, 112 ] ], "normalized": [] } ]
[]
[]
[]
1459
11829043:5
[ { "id": "1460", "type": "sentence", "text": [ "Results indicated that there was a significant decrease in both the C-STAI score ( F = 4.66 , P < 0.05 ) and the WHOQoL score ( F = 4.74 , P < 0.05 ) in the experimental group ." ], "offsets": [ [ 0, 177 ] ] } ]
[ { "id": "1461", "type": "outcome", "text": [ "C-STAI score" ], "offsets": [ [ 68, 80 ] ], "normalized": [] }, { "id": "1462", "type": "outcome", "text": [ "WHOQoL score" ], "offsets": [ [ 113, 125 ] ], "normalized": [] } ]
[]
[]
[]
1463
19802506:3
[ { "id": "1464", "type": "sentence", "text": [ "This study examined whether ( 1 ) postmenopausal breast cancer survivors ( BCS ) with bone loss taking 24 months of risedronate , calcium , and vitamin D had increased bone mineral density ( BMD ) at the total hip , femoral neck , L1-L4 spine , total radius and 33 % radius , and decreased bone turnover ; ( 2 ) subjects who also participated in strength/weight training ( ST ) exercises had greater increases in BMD and greater decreases in bone turnover ; and ( 3 ) subjects who also exercised were more likely to preserve ( at least maintain ) BMD ." ], "offsets": [ [ 0, 552 ] ] } ]
[ { "id": "1465", "type": "intervention", "text": [ "risedronate" ], "offsets": [ [ 116, 127 ] ], "normalized": [] }, { "id": "1466", "type": "intervention", "text": [ "calcium" ], "offsets": [ [ 130, 137 ] ], "normalized": [] }, { "id": "1467", "type": "intervention", "text": [ "vitamin D" ], "offsets": [ [ 144, 153 ] ], "normalized": [] }, { "id": "1468", "type": "intervention", "text": [ "strength/weight training ( ST ) exercises" ], "offsets": [ [ 346, 387 ] ], "normalized": [] }, { "id": "1469", "type": "outcome", "text": [ "bone mineral density ( BMD ) at the total hip , femoral neck , L1-L4 spine , total radius" ], "offsets": [ [ 168, 257 ] ], "normalized": [] }, { "id": "1470", "type": "outcome", "text": [ "bone turnover" ], "offsets": [ [ 290, 303 ] ], "normalized": [] }, { "id": "1471", "type": "outcome", "text": [ "BMD" ], "offsets": [ [ 191, 194 ] ], "normalized": [] }, { "id": "1472", "type": "outcome", "text": [ "bone turnover" ], "offsets": [ [ 290, 303 ] ], "normalized": [] }, { "id": "1473", "type": "outcome", "text": [ "BMD" ], "offsets": [ [ 191, 194 ] ], "normalized": [] }, { "id": "1474", "type": "participant", "text": [ "postmenopausal breast cancer survivors ( BCS ) with bone loss" ], "offsets": [ [ 34, 95 ] ], "normalized": [] } ]
[]
[]
[]
1475
21896676:10
[ { "id": "1476", "type": "sentence", "text": [ "A physiotherapy service for EECU patients , as provided in this study , did not reduce the rate of hospital admission , rate of re-presentation to the ED , use of community healthcare resources , or improve the rate of return to usual work/home/leisure activities or patient satisfaction ." ], "offsets": [ [ 0, 289 ] ] } ]
[ { "id": "1477", "type": "intervention", "text": [ "physiotherapy service" ], "offsets": [ [ 2, 23 ] ], "normalized": [] }, { "id": "1478", "type": "outcome", "text": [ "rate of hospital admission , rate of re-presentation to the ED , use of community healthcare resources" ], "offsets": [ [ 91, 193 ] ], "normalized": [] }, { "id": "1479", "type": "outcome", "text": [ "rate of return to usual work/home/leisure activities or patient satisfaction" ], "offsets": [ [ 211, 287 ] ], "normalized": [] } ]
[]
[]
[]
1480
11737955:6
[ { "id": "1481", "type": "sentence", "text": [ "The latter metabolite is not formed in man through the mono-oxygenase pathway of cytochrome P450 ." ], "offsets": [ [ 0, 98 ] ] } ]
[]
[]
[]
[]
1482
7831628:6
[ { "id": "1483", "type": "sentence", "text": [ "The comparative results were very close ; mean difference ( bias ) +/- standard deviation ( precision ) was 0.05 ( 0.84 ) mmol/min/kPa ." ], "offsets": [ [ 0, 136 ] ] } ]
[]
[]
[]
[]
1484
11495215:2
[ { "id": "1485", "type": "sentence", "text": [ "Cardiovascular reactivity to psychological stress may be one mechanism for the enhanced risk , but the small number of studies examining whether OC users who smoke have greater reactivity have produced mixed results ." ], "offsets": [ [ 0, 217 ] ] } ]
[ { "id": "1486", "type": "intervention", "text": [ "OC" ], "offsets": [ [ 145, 147 ] ], "normalized": [] }, { "id": "1487", "type": "outcome", "text": [ "Cardiovascular reactivity" ], "offsets": [ [ 0, 25 ] ], "normalized": [] } ]
[]
[]
[]
1488
9816035:7
[ { "id": "1489", "type": "sentence", "text": [ "The end point of CALGB 8642 is to assess the difference in survival , toxicity , and overall response when limited exposure to Phase II agents precedes standard chemotherapy ." ], "offsets": [ [ 0, 175 ] ] } ]
[ { "id": "1490", "type": "outcome", "text": [ "assess the difference in survival , toxicity , and overall response" ], "offsets": [ [ 34, 101 ] ], "normalized": [] } ]
[]
[]
[]
1491
23021296:3
[ { "id": "1492", "type": "sentence", "text": [ "We conducted a study including 15 depressive patients who had been under antidepressant treatment for at least one month ." ], "offsets": [ [ 0, 122 ] ] } ]
[ { "id": "1493", "type": "participant", "text": [ "15 depressive patients who had been under antidepressant treatment for at least one month" ], "offsets": [ [ 31, 120 ] ], "normalized": [] } ]
[]
[]
[]
1494
21170734:0
[ { "id": "1495", "type": "sentence", "text": [ "Serum biochemical characteristics of Beluga , Huso huso ( L. ) , in response to blood sampling after clove powder solution exposure ." ], "offsets": [ [ 0, 133 ] ] } ]
[ { "id": "1496", "type": "outcome", "text": [ "Serum biochemical characteristics" ], "offsets": [ [ 0, 33 ] ], "normalized": [] }, { "id": "1497", "type": "participant", "text": [ "Beluga , Huso huso ( L. )" ], "offsets": [ [ 37, 62 ] ], "normalized": [] } ]
[]
[]
[]
1498
24451919:8
[ { "id": "1499", "type": "sentence", "text": [ "fMRI data showed that , under placebo , ASD boys underactivated medial prefrontal cortex ( mPFC ) , compared with control and ADHD boys ." ], "offsets": [ [ 0, 137 ] ] } ]
[ { "id": "1500", "type": "intervention", "text": [ "placebo" ], "offsets": [ [ 30, 37 ] ], "normalized": [] }, { "id": "1501", "type": "outcome", "text": [ "fMRI" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "1502", "type": "outcome", "text": [ "medial prefrontal cortex ( mPFC )" ], "offsets": [ [ 64, 97 ] ], "normalized": [] } ]
[]
[]
[]
1503
12960652:11
[ { "id": "1504", "type": "sentence", "text": [ "Using epigastric impedance we found that infants with partial or total intestinal obstruction had gastric phasic activity , which was not found in the control infants ." ], "offsets": [ [ 0, 168 ] ] } ]
[ { "id": "1505", "type": "intervention", "text": [ "epigastric impedance" ], "offsets": [ [ 6, 26 ] ], "normalized": [] }, { "id": "1506", "type": "outcome", "text": [ "epigastric impedance" ], "offsets": [ [ 6, 26 ] ], "normalized": [] }, { "id": "1507", "type": "participant", "text": [ "infants with partial or total intestinal obstruction" ], "offsets": [ [ 41, 93 ] ], "normalized": [] } ]
[]
[]
[]
1508
6421395:1
[ { "id": "1509", "type": "sentence", "text": [ "To study the effects of physical exercise on biochemical risk factors for ischaemic heart disease 31 healthy middle aged men undertook regular physical exercise for two months and 29 served as controls in a randomised trial ." ], "offsets": [ [ 0, 225 ] ] } ]
[ { "id": "1510", "type": "intervention", "text": [ "physical exercise" ], "offsets": [ [ 24, 41 ] ], "normalized": [] }, { "id": "1511", "type": "intervention", "text": [ "regular physical exercise" ], "offsets": [ [ 135, 160 ] ], "normalized": [] }, { "id": "1512", "type": "outcome", "text": [ "biochemical risk factors for ischaemic heart disease" ], "offsets": [ [ 45, 97 ] ], "normalized": [] }, { "id": "1513", "type": "participant", "text": [ "31 healthy middle aged men" ], "offsets": [ [ 98, 124 ] ], "normalized": [] } ]
[]
[]
[]
1514
24451919:10
[ { "id": "1515", "type": "sentence", "text": [ "Under Fluoxetine , mPFC activation was up-regulated and normalized in ASD boys relative to controls , but down-regulated in ADHD boys relative to placebo , which was concomitant with worse task performance in ADHD ." ], "offsets": [ [ 0, 215 ] ] } ]
[ { "id": "1516", "type": "intervention", "text": [ "Fluoxetine" ], "offsets": [ [ 6, 16 ] ], "normalized": [] }, { "id": "1517", "type": "intervention", "text": [ "placebo" ], "offsets": [ [ 146, 153 ] ], "normalized": [] }, { "id": "1518", "type": "outcome", "text": [ "mPFC activation" ], "offsets": [ [ 19, 34 ] ], "normalized": [] }, { "id": "1519", "type": "outcome", "text": [ "task performance" ], "offsets": [ [ 189, 205 ] ], "normalized": [] } ]
[]
[]
[]
1520
10390665:7
[ { "id": "1521", "type": "sentence", "text": [ "We conclude that granisetron is a better anti-emetic than perphenazine for the long-term prevention of post-operative vomiting in children undergoing general anaesthesia for tonsillectomy ." ], "offsets": [ [ 0, 189 ] ] } ]
[ { "id": "1522", "type": "intervention", "text": [ "granisetron" ], "offsets": [ [ 17, 28 ] ], "normalized": [] }, { "id": "1523", "type": "intervention", "text": [ "perphenazine" ], "offsets": [ [ 58, 70 ] ], "normalized": [] }, { "id": "1524", "type": "outcome", "text": [ "long-term prevention of post-operative vomiting" ], "offsets": [ [ 79, 126 ] ], "normalized": [] }, { "id": "1525", "type": "participant", "text": [ "children undergoing general anaesthesia for tonsillectomy ." ], "offsets": [ [ 130, 189 ] ], "normalized": [] } ]
[]
[]
[]
1526
18337284:13
[ { "id": "1527", "type": "sentence", "text": [ "One case of unsubstantiated acute rheumatic fever occurred after 7 days of amoxicillin ." ], "offsets": [ [ 0, 88 ] ] } ]
[ { "id": "1528", "type": "intervention", "text": [ "amoxicillin" ], "offsets": [ [ 75, 86 ] ], "normalized": [] } ]
[]
[]
[]
1529
11317090:12
[ { "id": "1530", "type": "sentence", "text": [ "Costs/QALY gained discounted at 3 % were $ 205,186 using the QWB and $ 32,643 using the CHRD ." ], "offsets": [ [ 0, 94 ] ] } ]
[ { "id": "1531", "type": "outcome", "text": [ "Costs/QALY" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "1532", "type": "outcome", "text": [ "QWB" ], "offsets": [ [ 61, 64 ] ], "normalized": [] }, { "id": "1533", "type": "outcome", "text": [ "CHRD" ], "offsets": [ [ 88, 92 ] ], "normalized": [] } ]
[]
[]
[]
1534
20560622:5
[ { "id": "1535", "type": "sentence", "text": [ "Calcium solubility and absorption across Caco-2 cells were studied after the in vitro digestion of the diets ." ], "offsets": [ [ 0, 110 ] ] } ]
[ { "id": "1536", "type": "outcome", "text": [ "Calcium solubility and absorption across Caco-2 cells" ], "offsets": [ [ 0, 53 ] ], "normalized": [] } ]
[]
[]
[]
1537
20560622:0
[ { "id": "1538", "type": "sentence", "text": [ "Influence of diets rich in Maillard reaction products on calcium bioavailability ." ], "offsets": [ [ 0, 82 ] ] } ]
[ { "id": "1539", "type": "intervention", "text": [ "Maillard reaction products" ], "offsets": [ [ 27, 53 ] ], "normalized": [] }, { "id": "1540", "type": "outcome", "text": [ "calcium bioavailability" ], "offsets": [ [ 57, 80 ] ], "normalized": [] } ]
[]
[]
[]
1541
9816035:12
[ { "id": "1542", "type": "sentence", "text": [ "Prior adjuvant chemotherapy was permitted ." ], "offsets": [ [ 0, 43 ] ] } ]
[ { "id": "1543", "type": "participant", "text": [ "Prior adjuvant chemotherapy was permitted" ], "offsets": [ [ 0, 41 ] ], "normalized": [] } ]
[]
[]
[]
1544
23021296:8
[ { "id": "1545", "type": "sentence", "text": [ "Depressive patients are able to follow prescribed lifestyle recommendations in the short-term ." ], "offsets": [ [ 0, 95 ] ] } ]
[ { "id": "1546", "type": "intervention", "text": [ "lifestyle recommendations" ], "offsets": [ [ 50, 75 ] ], "normalized": [] }, { "id": "1547", "type": "participant", "text": [ "Depressive patients" ], "offsets": [ [ 0, 19 ] ], "normalized": [] } ]
[]
[]
[]
1548
2678230:1
[ { "id": "1549", "type": "sentence", "text": [ "The influence of injections of Amidotrizoate and Iopromide into the left coronary artery on global myocardial perfusion and function ( pressures in the left ventricle , heart rate ) as well as excitation formation and transmission was studied in 16 patients with ischaemic heart disease ." ], "offsets": [ [ 0, 288 ] ] } ]
[ { "id": "1550", "type": "intervention", "text": [ "Amidotrizoate" ], "offsets": [ [ 31, 44 ] ], "normalized": [] }, { "id": "1551", "type": "intervention", "text": [ "Iopromide" ], "offsets": [ [ 49, 58 ] ], "normalized": [] }, { "id": "1552", "type": "outcome", "text": [ "global myocardial perfusion and function ( pressures in the left ventricle , heart rate" ], "offsets": [ [ 92, 179 ] ], "normalized": [] }, { "id": "1553", "type": "outcome", "text": [ "excitation formation and transmission" ], "offsets": [ [ 193, 230 ] ], "normalized": [] }, { "id": "1554", "type": "participant", "text": [ "16 patients with ischaemic heart disease" ], "offsets": [ [ 246, 286 ] ], "normalized": [] } ]
[]
[]
[]
1555
11750293:3
[ { "id": "1556", "type": "sentence", "text": [ "These 22 patients constituted the control group of a controlled trial and received standard outpatient clinic treatment during follow-up ." ], "offsets": [ [ 0, 138 ] ] } ]
[ { "id": "1557", "type": "intervention", "text": [ "standard outpatient clinic treatment" ], "offsets": [ [ 83, 119 ] ], "normalized": [] }, { "id": "1558", "type": "participant", "text": [ "22 patients" ], "offsets": [ [ 6, 17 ] ], "normalized": [] } ]
[]
[]
[]
1559
9816035:11
[ { "id": "1560", "type": "sentence", "text": [ "Patients could not have had prior chemotherapy for metastatic disease ." ], "offsets": [ [ 0, 71 ] ] } ]
[ { "id": "1561", "type": "participant", "text": [ "Patients could not have had prior chemotherapy for metastatic disease" ], "offsets": [ [ 0, 69 ] ], "normalized": [] } ]
[]
[]
[]
1562
9816035:9
[ { "id": "1563", "type": "sentence", "text": [ "Comparisons with the cyclophosphamide-doxorubicin-5-fluorouracil arm will not be addressed ." ], "offsets": [ [ 0, 92 ] ] } ]
[ { "id": "1564", "type": "intervention", "text": [ "cyclophosphamide-doxorubicin-5-fluorouracil" ], "offsets": [ [ 21, 64 ] ], "normalized": [] } ]
[]
[]
[]
1565
24515505:4
[ { "id": "1566", "type": "sentence", "text": [ "Children with parent-reported ASD had higher levels of health care office visits and prescription drug use compared with children without ASD ( P < .05 ) ." ], "offsets": [ [ 0, 155 ] ] } ]
[ { "id": "1567", "type": "outcome", "text": [ "health care office visits and prescription drug use" ], "offsets": [ [ 55, 106 ] ], "normalized": [] }, { "id": "1568", "type": "participant", "text": [ "Children with parent-reported ASD" ], "offsets": [ [ 0, 33 ] ], "normalized": [] } ]
[]
[]
[]
1569
12960652:10
[ { "id": "1570", "type": "sentence", "text": [ "Short-term phasic activity was only found in 13 out of 40 of the normal infants ( 32.5 % ) ." ], "offsets": [ [ 0, 92 ] ] } ]
[ { "id": "1571", "type": "outcome", "text": [ "phasic activity" ], "offsets": [ [ 11, 26 ] ], "normalized": [] } ]
[]
[]
[]
1572
23103798:3
[ { "id": "1573", "type": "sentence", "text": [ "Group 1 received a weekly session of posterior tibial nerve stimulation for 12 weeks and group 2 was the placebo group ." ], "offsets": [ [ 0, 120 ] ] } ]
[ { "id": "1574", "type": "intervention", "text": [ "posterior tibial nerve stimulation" ], "offsets": [ [ 37, 71 ] ], "normalized": [] }, { "id": "1575", "type": "intervention", "text": [ "placebo" ], "offsets": [ [ 105, 112 ] ], "normalized": [] } ]
[]
[]
[]
1576
20560622:9
[ { "id": "1577", "type": "sentence", "text": [ "Only deoxypyridinoline values were significantly lower after consumption of the BD ( 13.0 +/- 1.1 compared to 18.3 +/- 2.1 nM/Mm Cr in the WD ) , possibly indicative of less efficient bone turnover during this period ." ], "offsets": [ [ 0, 218 ] ] } ]
[ { "id": "1578", "type": "outcome", "text": [ "deoxypyridinoline" ], "offsets": [ [ 5, 22 ] ], "normalized": [] }, { "id": "1579", "type": "outcome", "text": [ "bone turnover" ], "offsets": [ [ 184, 197 ] ], "normalized": [] } ]
[]
[]
[]
1580
11829043:8
[ { "id": "1581", "type": "sentence", "text": [ "The results suggest that the use of PMRT could enhance quality of life and decrease state anxiety in patients after stoma surgery ." ], "offsets": [ [ 0, 131 ] ] } ]
[ { "id": "1582", "type": "intervention", "text": [ "PMRT" ], "offsets": [ [ 36, 40 ] ], "normalized": [] }, { "id": "1583", "type": "outcome", "text": [ "quality of life" ], "offsets": [ [ 55, 70 ] ], "normalized": [] }, { "id": "1584", "type": "outcome", "text": [ "anxiety" ], "offsets": [ [ 90, 97 ] ], "normalized": [] }, { "id": "1585", "type": "participant", "text": [ "patients after stoma surgery ." ], "offsets": [ [ 101, 131 ] ], "normalized": [] } ]
[]
[]
[]
1586
18229990:4
[ { "id": "1587", "type": "sentence", "text": [ "Interventions were conducted 30 min daily for 5-6 weeks ." ], "offsets": [ [ 0, 57 ] ] } ]
[]
[]
[]
[]
1588
11891832:4
[ { "id": "1589", "type": "sentence", "text": [ "There were also no differences in manual muscle testing sum scores , activity scale scores and patients ' own assessments after 48 weeks of treatment ." ], "offsets": [ [ 0, 151 ] ] } ]
[ { "id": "1590", "type": "outcome", "text": [ "manual muscle testing sum scores , activity scale scores and patients ' own assessments" ], "offsets": [ [ 34, 121 ] ], "normalized": [] } ]
[]
[]
[]
1591
23356250:8
[ { "id": "1592", "type": "sentence", "text": [ "However , transfusion rate , presence of hepatomegaly , splenomegaly , and jaundice was similar ." ], "offsets": [ [ 0, 97 ] ] } ]
[ { "id": "1593", "type": "outcome", "text": [ "transfusion rate , presence of hepatomegaly , splenomegaly , and jaundice" ], "offsets": [ [ 10, 83 ] ], "normalized": [] } ]
[]
[]
[]
1594
16505427:3
[ { "id": "1595", "type": "sentence", "text": [ "Three hundred sixty-five patients were enrolled ." ], "offsets": [ [ 0, 49 ] ] } ]
[ { "id": "1596", "type": "participant", "text": [ "Three hundred sixty-five patients" ], "offsets": [ [ 0, 33 ] ], "normalized": [] } ]
[]
[]
[]
1597
20618920:7
[ { "id": "1598", "type": "sentence", "text": [ "If so , this would be a great support for doctors who might systematically recommend these simple and costless measures , especially in primary care ." ], "offsets": [ [ 0, 150 ] ] } ]
[]
[]
[]
[]