dwb2023/family-target-interaction-ligand-gtopdb

family_id int64 1 1.1k	family_type stringclasses 9 values	family_name stringclasses 590 values	target_id int64 1 3.29k	target_name stringlengths 3 122	interaction_id int64 1 90.9k	interaction_type stringclasses 10 values	interaction_action stringclasses 24 values	primary_target bool 2 classes	affinity_median float64 0.3 13 ⌀	affinity_units stringclasses 7 values	ligand_id int64 1 13.4k	ligand_name stringlengths 2 141	ligand_type stringclasses 6 values	ligand_approved bool 2 classes	ligand_approval_source stringclasses 439 values	pubchem_sid float64 53.8M 491M ⌀
317	catalytic_receptor	NOD-like receptor family	1,770	NLRP3	85,476	Inhibitor	Inhibition	false	null	-	10,056	dapansutrile	Synthetic organic	false	null	375,973,244
317	catalytic_receptor	NOD-like receptor family	1,770	NLRP3	88,900	Inhibitor	Inhibition	false	6.85	pIC50	12,172	emlenoflast	Synthetic organic	false	null	472,319,294
317	catalytic_receptor	NOD-like receptor family	1,770	NLRP3	89,015	Allosteric modulator	Inhibition	false	7.29	pIC50	12,280	GDC-2394	Synthetic organic	false	null	473,153,868
317	catalytic_receptor	NOD-like receptor family	1,770	NLRP3	81,832	Inhibitor	Inhibition	false	8	pIC50	8,228	MCC950	Synthetic organic	false	null	249,565,908
317	catalytic_receptor	NOD-like receptor family	1,770	NLRP3	90,152	Inhibitor	Inhibition	false	7.18	pIC50	13,009	NDT-19795	Synthetic organic	false	null	485,206,130
317	catalytic_receptor	NOD-like receptor family	1,770	NLRP3	90,526	Inhibitor	Inhibition	false	null	-	13,184	nibrozetone	Synthetic organic	false	null	491,299,966
317	catalytic_receptor	NOD-like receptor family	1,770	NLRP3	90,732	Inhibitor	Inhibition	false	7.96	pIC50	13,338	NT-0249	Synthetic organic	false	null	null
317	catalytic_receptor	NOD-like receptor family	1,770	NLRP3	90,151	Inhibitor	Inhibition	false	9.49	pIC50	13,008	NT-0796	Synthetic organic	false	null	485,206,129
317	catalytic_receptor	NOD-like receptor family	1,770	NLRP3	90,243	Inhibitor	Inhibition	false	7.28	pKd	13,088	oridonin	Natural product	false	null	491,299,870
317	catalytic_receptor	NOD-like receptor family	1,770	NLRP3	90,860	Inhibitor	Inhibition	false	7.11	pIC50	13,421	oridonin derivative 32 [PMID: 38751194]	Synthetic organic	false	null	null
317	catalytic_receptor	NOD-like receptor family	1,770	NLRP3	88,901	Inhibitor	Inhibition	false	6	pIC50	12,173	selnoflast	Synthetic organic	false	null	472,319,295
317	catalytic_receptor	NOD-like receptor family	1,766	NLRX1	90,801	Activator	Activation	false	4.52	pKd	13,384	amelenodor	Synthetic organic	false	null	null
317	catalytic_receptor	NOD-like receptor family	1,762	nucleotide binding oligomerization domain containing 1	13,475	Agonist	Agonist	null	null	-	5,021	meso-DAP	Natural product	false	null	178,101,718
317	catalytic_receptor	NOD-like receptor family	1,762	nucleotide binding oligomerization domain containing 1	83,011	Inhibitor	Inhibition	true	6.25	pIC50	8,887	ML130	Synthetic organic	false	null	310,264,668
317	catalytic_receptor	NOD-like receptor family	1,763	nucleotide binding oligomerization domain containing 2	83,012	Inhibitor	Inhibition	false	4.7	pIC50	8,887	ML130	Synthetic organic	false	null	310,264,668
317	catalytic_receptor	NOD-like receptor family	1,763	nucleotide binding oligomerization domain containing 2	13,476	Agonist	Agonist	null	null	-	5,024	muramyl dipeptide	Natural product	false	null	178,101,721
309	catalytic_receptor	Prolactin receptor family	1,718	Eythropoietin receptor	84,592	Agonist	Agonist	true	null	-	9,677	cibinetide	Peptide	false	null	348,353,636
309	catalytic_receptor	Prolactin receptor family	1,718	Eythropoietin receptor	13,431	Agonist	Agonist	false	11.15	pIC50	4,921	erythropoietin	Peptide	true	FDA (no history prior to 1989 available)	178,101,620
309	catalytic_receptor	Prolactin receptor family	1,718	Eythropoietin receptor	79,747	Agonist	Agonist	true	10.43	pIC50	7,447	peginesatide	Peptide	true	FDA (2012)	178,104,019
309	catalytic_receptor	Prolactin receptor family	1,719	Granulocyte colony-stimulating factor receptor	88,337	Antibody	Binding	true	8.85	pKd	11,761	anumigilimab	Antibody	false	null	458,923,796
309	catalytic_receptor	Prolactin receptor family	1,719	Granulocyte colony-stimulating factor receptor	88,338	Antibody	Binding	false	9.31	pKd	11,761	anumigilimab	Antibody	false	null	458,923,796
309	catalytic_receptor	Prolactin receptor family	1,719	Granulocyte colony-stimulating factor receptor	13,432	Agonist	Agonist	null	null	-	4,934	G-CSF	Peptide	true	null	178,101,632
309	catalytic_receptor	Prolactin receptor family	1,719	Granulocyte colony-stimulating factor receptor	79,223	Agonist	Agonist	true	null	-	6,969	pegfilgrastim	Peptide	true	FDA and EMA (2002)	178,103,549
309	catalytic_receptor	Prolactin receptor family	1,720	Growth hormone receptor	13,433	Agonist	Agonist	true	9.04	pKd	4,943	growth hormone 1	Peptide	true	FDA (1976), EMA (2001)	178,101,641
309	catalytic_receptor	Prolactin receptor family	1,720	Growth hormone receptor	13,434	Agonist	Agonist	null	null	-	4,944	growth hormone 2	Peptide	false	null	178,101,642
309	catalytic_receptor	Prolactin receptor family	1,720	Growth hormone receptor	79,795	Antagonist	Antagonist	true	null	-	7,485	pegvisomant	Peptide	true	FDA (2003), EMA (2008)	187,051,788
309	catalytic_receptor	Prolactin receptor family	1,720	Growth hormone receptor	88,698	Agonist	Agonist	false	8.29	pKd	12,013	somatrogon	Peptide	true	EMA (2022), FDA (2023)	464,244,154
309	catalytic_receptor	Prolactin receptor family	1,720	Growth hormone receptor	88,697	Agonist	Agonist	false	8.2	pKd	12,013	somatrogon	Peptide	true	EMA (2022), FDA (2023)	464,244,154
309	catalytic_receptor	Prolactin receptor family	1,720	Growth hormone receptor	88,699	Agonist	Agonist	false	7.94	pKd	12,013	somatrogon	Peptide	true	EMA (2022), FDA (2023)	464,244,154
309	catalytic_receptor	Prolactin receptor family	1,721	Prolactin receptor	77,615	Agonist	Agonist	null	null	-	4,893	choriomammotropin	Peptide	false	null	178,101,593
309	catalytic_receptor	Prolactin receptor family	1,721	Prolactin receptor	77,616	Agonist	Agonist	null	null	-	4,894	chorionic somatomammotropin hormone-like 1	Peptide	false	null	178,101,594
309	catalytic_receptor	Prolactin receptor family	1,721	Prolactin receptor	77,614	Agonist	Agonist	false	8.05	pKd	5,049	prolactin	Peptide	false	null	178,101,744
309	catalytic_receptor	Prolactin receptor family	1,722	Thrombopoietin receptor	85,215	Agonist	Agonist	false	null	-	9,953	avatrombopag	Synthetic organic	true	FDA (2018), EMA (2019)	374,883,840
309	catalytic_receptor	Prolactin receptor family	1,722	Thrombopoietin receptor	79,046	Agonist	Agonist	true	7.42	pEC50	6,961	eltrombopag	Synthetic organic	true	FDA (2008), EMA (2010)	178,103,542
309	catalytic_receptor	Prolactin receptor family	1,722	Thrombopoietin receptor	87,052	Agonist	Agonist	false	null	-	10,657	hetrombopag	Synthetic organic	true	China (2021)	404,859,104
309	catalytic_receptor	Prolactin receptor family	1,722	Thrombopoietin receptor	85,433	Agonist	Agonist	true	null	-	10,032	lusutrombopag	Synthetic organic	true	Japan (2015), FDA (2018), EMA (2019)	375,973,220
309	catalytic_receptor	Prolactin receptor family	1,722	Thrombopoietin receptor	79,045	Agonist	Agonist	true	null	-	6,974	romiplostim	Peptide	true	FDA (2008), EMA (2009)	178,103,553
309	catalytic_receptor	Prolactin receptor family	1,722	Thrombopoietin receptor	13,436	Agonist	Agonist	null	null	-	5,063	thrombopoietin	Peptide	false	null	178,101,756
333	catalytic_receptor	Receptor tyrosine phosphatase (RTP) family	1,851	RTP Type B	82,785	Inhibitor	Inhibition	false	7.15	pIC50	8,786	compound 13e [PMID: 16759857]	Synthetic organic	false	null	252,827,444
333	catalytic_receptor	Receptor tyrosine phosphatase (RTP) family	1,851	RTP Type B	87,728	Inhibitor	Inhibition	false	6.15	pIC50	11,336	razuprotafib	Synthetic organic	false	null	440,816,705
333	catalytic_receptor	Receptor tyrosine phosphatase (RTP) family	1,853	RTP Type D	85,643	Inhibitor	Inhibition	true	null	pIC50	10,109	7-BIA	Synthetic organic	false	null	381,118,819
333	catalytic_receptor	Receptor tyrosine phosphatase (RTP) family	1,855	RTP Type F	82,742	Inhibitor	Inhibition	false	5.89	pIC50	8,770	illudalic acid	Synthetic organic	false	null	252,827,428
333	catalytic_receptor	Receptor tyrosine phosphatase (RTP) family	1,856	RTP Type G	82,872	Inhibitor	Inhibition	false	5.6	pKi	8,831	compound 1 [PMID: 21882820]	Synthetic organic	false	null	252,827,488
333	catalytic_receptor	Receptor tyrosine phosphatase (RTP) family	1,860	RTP Type M	82,925	Inhibitor	Inhibition	false	5.15	pIC50	8,856	compound 8a [PMID: 23713581]	Synthetic organic	false	null	252,827,513
333	catalytic_receptor	Receptor tyrosine phosphatase (RTP) family	1,866	RTP Type S	85,644	Inhibitor	Inhibition	false	4.4	pIC50	10,109	7-BIA	Synthetic organic	false	null	381,118,819
333	catalytic_receptor	Receptor tyrosine phosphatase (RTP) family	1,866	RTP Type S	82,915	Inhibitor	Inhibition	false	5.44	pIC50	8,850	compound 7b [Haftchenary <i>et al.</i>, 2013]	Synthetic organic	false	null	252,827,507
940	catalytic_receptor	RIG-I-like receptor family	2,920	DExD/H-box helicase 58	88,378	Agonist	Agonist	false	null	-	11,795	SLR14	Synthetic organic	false	null	458,923,830
797	catalytic_receptor	RSTK functional heteromers	2,588	Activin receptors	79,955	Agonist	Agonist	false	null	-	4,857	activin A	Peptide	false	null	178,101,558
797	catalytic_receptor	RSTK functional heteromers	2,588	Activin receptors	79,958	Agonist	Agonist	false	null	-	4,858	activin AB	Peptide	false	null	178,101,559
797	catalytic_receptor	RSTK functional heteromers	2,588	Activin receptors	79,956	Agonist	Agonist	false	null	-	4,859	activin B	Peptide	false	null	178,101,560
797	catalytic_receptor	RSTK functional heteromers	2,588	Activin receptors	79,957	Agonist	Agonist	false	null	-	5,010	inhibin A	Peptide	false	null	178,101,707
797	catalytic_receptor	RSTK functional heteromers	2,589	Anti-Müllerian hormone receptors	78,668	Agonist	Agonist	null	null	-	6,686	Müllerian inhibiting substance	Peptide	false	null	178,103,298
797	catalytic_receptor	RSTK functional heteromers	2,586	Bone morphogenetic protein receptors	78,661	Agonist	Agonist	null	null	-	4,875	BMP-10	Peptide	false	null	178,101,575
797	catalytic_receptor	RSTK functional heteromers	2,586	Bone morphogenetic protein receptors	78,653	Agonist	Agonist	null	null	-	4,881	BMP-2	Peptide	false	null	178,101,581
797	catalytic_receptor	RSTK functional heteromers	2,586	Bone morphogenetic protein receptors	78,654	Agonist	Agonist	null	null	-	4,883	BMP-4	Peptide	false	null	178,101,583
797	catalytic_receptor	RSTK functional heteromers	2,586	Bone morphogenetic protein receptors	78,655	Agonist	Agonist	null	null	-	4,884	BMP-5	Peptide	false	null	178,101,584
797	catalytic_receptor	RSTK functional heteromers	2,586	Bone morphogenetic protein receptors	78,656	Agonist	Agonist	null	null	-	4,885	BMP-6	Peptide	false	null	178,101,585
797	catalytic_receptor	RSTK functional heteromers	2,586	Bone morphogenetic protein receptors	78,657	Agonist	Agonist	null	null	-	4,886	BMP-7	Peptide	false	null	178,101,586
797	catalytic_receptor	RSTK functional heteromers	2,586	Bone morphogenetic protein receptors	78,658	Agonist	Agonist	null	null	-	4,887	BMP-8A	Peptide	false	null	178,101,587
797	catalytic_receptor	RSTK functional heteromers	2,586	Bone morphogenetic protein receptors	78,659	Agonist	Agonist	null	null	-	4,888	BMP-8B	Peptide	false	null	178,101,588
797	catalytic_receptor	RSTK functional heteromers	2,586	Bone morphogenetic protein receptors	78,660	Agonist	Agonist	null	null	-	4,889	BMP-9	Peptide	false	null	178,101,589
797	catalytic_receptor	RSTK functional heteromers	2,587	Growth/differentiation factor receptors	78,662	Agonist	Agonist	null	null	-	4,936	growth/differentiation factor-1	Peptide	false	null	178,101,634
797	catalytic_receptor	RSTK functional heteromers	2,587	Growth/differentiation factor receptors	78,665	Agonist	Agonist	null	null	-	4,937	growth/differentiation factor-10	Peptide	false	null	178,101,635
797	catalytic_receptor	RSTK functional heteromers	2,587	Growth/differentiation factor receptors	78,663	Agonist	Agonist	null	null	-	4,938	growth/differentiation factor-3	Peptide	false	null	178,101,636
797	catalytic_receptor	RSTK functional heteromers	2,587	Growth/differentiation factor receptors	81,905	Agonist	Agonist	false	null	-	4,877	growth/differentiation factor-7	Peptide	false	null	178,101,577
797	catalytic_receptor	RSTK functional heteromers	2,587	Growth/differentiation factor receptors	78,664	Agonist	Agonist	null	null	-	4,939	growth/differentiation factor-9	Peptide	false	null	178,101,637
797	catalytic_receptor	RSTK functional heteromers	2,585	Transforming growth factor β receptor	78,650	Agonist	Agonist	null	null	-	5,060	TGFβ1	Peptide	false	null	178,101,753
797	catalytic_receptor	RSTK functional heteromers	2,585	Transforming growth factor β receptor	78,651	Agonist	Agonist	null	null	-	5,061	TGFβ2	Peptide	false	null	178,101,754
797	catalytic_receptor	RSTK functional heteromers	2,585	Transforming growth factor β receptor	78,652	Agonist	Agonist	null	null	-	5,062	TGFβ3	Peptide	false	null	178,101,755
316	catalytic_receptor	Toll-like receptor family	1,752	TLR2	83,029	Agonist	Agonist	false	7.6	pKi	8,888	compound 13 [PMID: 23098072]	Synthetic organic	false	null	310,264,669
316	catalytic_receptor	Toll-like receptor family	1,752	TLR2	83,394	Agonist	Agonist	false	null	-	9,024	defoslimod	Synthetic organic	false	null	315,661,109
316	catalytic_receptor	Toll-like receptor family	1,752	TLR2	86,260	Agonist	Agonist	false	9.96	pEC50	10,341	diprovocim-1	Synthetic organic	false	null	381,745,022
316	catalytic_receptor	Toll-like receptor family	1,752	TLR2	13,464	Agonist	Agonist	null	null	-	5,044	peptidoglycan	Natural product	false	null	178,101,739
316	catalytic_receptor	Toll-like receptor family	1,752	TLR2	84,052	Antibody	Binding	false	7.92	pKd	9,408	tomaralimab	Antibody	false	null	328,083,510
316	catalytic_receptor	Toll-like receptor family	1,752	TLR2	84,051	Antibody	Binding	true	7.54	pKd	9,408	tomaralimab	Antibody	false	null	328,083,510
316	catalytic_receptor	Toll-like receptor family	1,753	TLR3	13,465	Agonist	Agonist	null	null	-	5,047	poly(I:C)	Synthetic organic	false	null	178,101,742
316	catalytic_receptor	Toll-like receptor family	1,754	TLR4	85,558	Agonist	Partial agonist	false	null	-	10,091	CRX-555	Synthetic organic	false	null	381,118,801
316	catalytic_receptor	Toll-like receptor family	1,754	TLR4	83,395	Agonist	Agonist	false	null	-	9,024	defoslimod	Synthetic organic	false	null	315,661,109
316	catalytic_receptor	Toll-like receptor family	1,754	TLR4	87,398	Agonist	Agonist	false	9.77	pEC50	11,150	GSK1795091	Synthetic organic	false	null	434,122,210
316	catalytic_receptor	Toll-like receptor family	1,754	TLR4	13,466	Agonist	Agonist	null	null	-	5,019	LPS	Natural product	false	null	178,101,716
316	catalytic_receptor	Toll-like receptor family	1,754	TLR4	84,390	Agonist	Agonist	false	null	-	9,137	neoceptin-3	Synthetic organic	false	null	315,661,222
316	catalytic_receptor	Toll-like receptor family	1,754	TLR4	13,467	Agonist	Agonist	false	null	-	2,770	paclitaxel	Natural product	true	FDA (1992), EMA (2008)	135,652,721
316	catalytic_receptor	Toll-like receptor family	1,754	TLR4	83,405	Antagonist	Antagonist	true	null	-	9,036	resatorvid	Synthetic organic	false	null	315,661,121
316	catalytic_receptor	Toll-like receptor family	1,755	TLR5	13,468	Agonist	Agonist	false	null	-	4,931	flagellin	Natural product	false	null	178,101,629
316	catalytic_receptor	Toll-like receptor family	1,757	TLR7	83,397	Agonist	Agonist	false	5.21	pEC50	9,025	852A	Synthetic organic	false	null	315,661,110
316	catalytic_receptor	Toll-like receptor family	1,757	TLR7	83,396	Agonist	Agonist	false	5.58	pEC50	9,025	852A	Synthetic organic	false	null	315,661,110
316	catalytic_receptor	Toll-like receptor family	1,757	TLR7	86,594	Antagonist	Antagonist	false	5.09	pIC50	10,435	compound 10a [PMID: 31283223]	Synthetic organic	false	null	385,612,195
316	catalytic_receptor	Toll-like receptor family	1,757	TLR7	88,657	Agonist	Agonist	false	3.42	pEC50	11,977	compound 27 [WO2019226977A1]	Synthetic organic	false	null	464,244,118
316	catalytic_receptor	Toll-like receptor family	1,757	TLR7	87,657	Antagonist	Antagonist	false	6	pIC50	11,307	enpatoran	Synthetic organic	false	null	434,321,742
316	catalytic_receptor	Toll-like receptor family	1,757	TLR7	83,732	Agonist	Agonist	true	null	-	9,254	GSK2245035	Synthetic organic	false	null	315,661,329
316	catalytic_receptor	Toll-like receptor family	1,757	TLR7	79,583	Antagonist	Antagonist	true	5.56	pIC50	7,198	hydroxychloroquine	Synthetic organic	true	FDA (1955)	178,103,773
316	catalytic_receptor	Toll-like receptor family	1,757	TLR7	13,470	Agonist	Agonist	true	4.94	pEC50	5,003	imiquimod	Synthetic organic	true	FDA (1997), EMA (1998)	178,101,700
316	catalytic_receptor	Toll-like receptor family	1,757	TLR7	13,471	Agonist	Agonist	null	null	-	5,018	loxoribine	Synthetic organic	false	null	178,101,715
316	catalytic_receptor	Toll-like receptor family	1,757	TLR7	13,469	Agonist	Agonist	false	5.87	pEC50	5,051	resiquimod	Synthetic organic	false	null	178,101,746
316	catalytic_receptor	Toll-like receptor family	1,758	TLR8	83,750	Agonist	Agonist	true	5.88	pEC50	9,270	3M-002	Synthetic organic	false	null	315,661,345
316	catalytic_receptor	Toll-like receptor family	1,758	TLR8	84,634	Agonist	Agonist	true	5.3	pEC50	9,690	compound 12p [Larson <i>et al.</i>, 2017]	Synthetic organic	false	null	348,353,649
316	catalytic_receptor	Toll-like receptor family	1,758	TLR8	88,668	Antagonist	Antagonist	false	8.7	pIC50	11,989	compound 15 [PMID: 35450354]	Synthetic organic	false	null	464,244,130
316	catalytic_receptor	Toll-like receptor family	1,758	TLR8	84,826	Inhibitor	Inhibition	false	6.66	pKd	9,795	CU-CPT8m	Synthetic organic	false	null	354,702,267
316	catalytic_receptor	Toll-like receptor family	1,758	TLR8	84,825	Inhibitor	Inhibition	false	7.17	pIC50	9,795	CU-CPT8m	Synthetic organic	false	null	354,702,267
316	catalytic_receptor	Toll-like receptor family	1,758	TLR8	83,398	Agonist	Agonist	false	7	pEC50	9,026	motolimod	Synthetic organic	false	null	315,661,111

317

catalytic_receptor

NOD-like receptor family

1,770

NLRP3

85,476

Inhibitor

Inhibition

false

null

-

10,056

dapansutrile

Synthetic organic

false

null

375,973,244

317

catalytic_receptor

NOD-like receptor family

1,770

NLRP3

88,900

Inhibitor

Inhibition

false

6.85

pIC50

12,172

emlenoflast

Synthetic organic

false

null

472,319,294

317

catalytic_receptor

NOD-like receptor family

1,770

NLRP3

89,015

Allosteric modulator

Inhibition

false

7.29

pIC50

12,280

GDC-2394

Synthetic organic

false

null

473,153,868

317

catalytic_receptor

NOD-like receptor family

1,770

NLRP3

81,832

Inhibitor

Inhibition

false

8

pIC50

8,228

MCC950

Synthetic organic

false

null

249,565,908

317

catalytic_receptor

NOD-like receptor family

1,770

NLRP3

90,152

Inhibitor

Inhibition

false

7.18

pIC50

13,009

NDT-19795

Synthetic organic

false

null

485,206,130

317

catalytic_receptor

NOD-like receptor family

1,770

NLRP3

90,526

Inhibitor

Inhibition

false

null

-

13,184

nibrozetone

Synthetic organic

false

null

491,299,966

317

catalytic_receptor

NOD-like receptor family

1,770

NLRP3

90,732

Inhibitor

Inhibition

false

7.96

pIC50

13,338

NT-0249

Synthetic organic

false

null

317

catalytic_receptor

NOD-like receptor family

1,770

NLRP3

90,151

Inhibitor

Inhibition

false

9.49

pIC50

13,008

NT-0796

Synthetic organic

false

null

485,206,129

317

catalytic_receptor

NOD-like receptor family

1,770

NLRP3

90,243

Inhibitor

Inhibition

false

7.28

pKd

13,088

oridonin

Natural product

false

null

491,299,870

317

catalytic_receptor

NOD-like receptor family

1,770

NLRP3

90,860

Inhibitor

Inhibition

false

7.11

pIC50

13,421

oridonin derivative 32 [PMID: 38751194]

Synthetic organic

false

null

317

catalytic_receptor

NOD-like receptor family

1,770

NLRP3

88,901

Inhibitor

Inhibition

false

6

pIC50

12,173

selnoflast

Synthetic organic

false

null

472,319,295

317

catalytic_receptor

NOD-like receptor family

1,766

NLRX1

90,801

Activator

Activation

false

4.52

pKd

13,384

amelenodor

Synthetic organic

false

null

317

catalytic_receptor

NOD-like receptor family

1,762

nucleotide binding oligomerization domain containing 1

13,475

Agonist

null

-

5,021

meso-DAP

Natural product

false

null

178,101,718

317

catalytic_receptor

NOD-like receptor family

1,762

nucleotide binding oligomerization domain containing 1

83,011

Inhibitor

Inhibition

true

6.25

pIC50

8,887

ML130

Synthetic organic

false

null

310,264,668

317

catalytic_receptor

NOD-like receptor family

1,763

nucleotide binding oligomerization domain containing 2

83,012

Inhibitor

Inhibition

false

4.7

pIC50

8,887

ML130

Synthetic organic

false

null

310,264,668

317

catalytic_receptor

NOD-like receptor family

1,763

nucleotide binding oligomerization domain containing 2

13,476

Agonist

null

-

5,024

muramyl dipeptide

Natural product

false

null

178,101,721

309

catalytic_receptor

Prolactin receptor family

1,718

Eythropoietin receptor

84,592

Agonist

true

null

-

9,677

cibinetide

Peptide

false

null

348,353,636

309

catalytic_receptor

Prolactin receptor family

1,718

Eythropoietin receptor

13,431

Agonist

false

11.15

pIC50

4,921

erythropoietin

Peptide

true

FDA (no history prior to 1989 available)

178,101,620

309

catalytic_receptor

Prolactin receptor family

1,718

Eythropoietin receptor

79,747

Agonist

true

10.43

pIC50

7,447

peginesatide

Peptide

true

FDA (2012)

178,104,019

309

catalytic_receptor

Prolactin receptor family

1,719

Granulocyte colony-stimulating factor receptor

88,337

Antibody

Binding

true

8.85

pKd

11,761

anumigilimab

Antibody

false

null

458,923,796

309

catalytic_receptor

Prolactin receptor family

1,719

Granulocyte colony-stimulating factor receptor

88,338

Antibody

Binding

false

9.31

pKd

11,761

anumigilimab

Antibody

false

null

458,923,796

309

catalytic_receptor

Prolactin receptor family

1,719

Granulocyte colony-stimulating factor receptor

13,432

Agonist

null

-

4,934

G-CSF

Peptide

true

null

178,101,632

309

catalytic_receptor

Prolactin receptor family

1,719

Granulocyte colony-stimulating factor receptor

79,223

Agonist

true

null

-

6,969

pegfilgrastim

Peptide

true

FDA and EMA (2002)

178,103,549

309

catalytic_receptor

Prolactin receptor family

1,720

Growth hormone receptor

13,433

Agonist

true

9.04

pKd

4,943

growth hormone 1

Peptide

true

FDA (1976), EMA (2001)

178,101,641

309

catalytic_receptor

Prolactin receptor family

1,720

Growth hormone receptor

13,434

Agonist

null

-

4,944

growth hormone 2

Peptide

false

null

178,101,642

309

catalytic_receptor

Prolactin receptor family

1,720

Growth hormone receptor

79,795

Antagonist

true

null

-

7,485

pegvisomant

Peptide

true

FDA (2003), EMA (2008)

187,051,788

309

catalytic_receptor

Prolactin receptor family

1,720

Growth hormone receptor

88,698

Agonist

false

8.29

pKd

12,013

somatrogon

Peptide

true

EMA (2022), FDA (2023)

464,244,154

309

catalytic_receptor

Prolactin receptor family

1,720

Growth hormone receptor

88,697

Agonist

false

8.2

pKd

12,013

somatrogon

Peptide

true

EMA (2022), FDA (2023)

464,244,154

309

catalytic_receptor

Prolactin receptor family

1,720

Growth hormone receptor

88,699

Agonist

false

7.94

pKd

12,013

somatrogon

Peptide

true

EMA (2022), FDA (2023)

464,244,154

309

catalytic_receptor

Prolactin receptor family

1,721

Prolactin receptor

77,615

Agonist

null

-

4,893

choriomammotropin

Peptide

false

null

178,101,593

309

catalytic_receptor

Prolactin receptor family

1,721

Prolactin receptor

77,616

Agonist

null

-

4,894

chorionic somatomammotropin hormone-like 1

Peptide

false

null

178,101,594

309

catalytic_receptor

Prolactin receptor family

1,721

Prolactin receptor

77,614

Agonist

false

8.05

pKd

5,049

prolactin

Peptide

false

null

178,101,744

309

catalytic_receptor

Prolactin receptor family

1,722

Thrombopoietin receptor

85,215

Agonist

false

null

-

9,953

avatrombopag

Synthetic organic

true

FDA (2018), EMA (2019)

374,883,840

309

catalytic_receptor

Prolactin receptor family

1,722

Thrombopoietin receptor

79,046

Agonist

true

7.42

pEC50

6,961

eltrombopag

Synthetic organic

true

FDA (2008), EMA (2010)

178,103,542

309

catalytic_receptor

Prolactin receptor family

1,722

Thrombopoietin receptor

87,052

Agonist

false

null

-

10,657

hetrombopag

Synthetic organic

true

China (2021)

404,859,104

309

catalytic_receptor

Prolactin receptor family

1,722

Thrombopoietin receptor

85,433

Agonist

true

null

-

10,032

lusutrombopag

Synthetic organic

true

Japan (2015), FDA (2018), EMA (2019)

375,973,220

309

catalytic_receptor

Prolactin receptor family

1,722

Thrombopoietin receptor

79,045

Agonist

true

null

-

6,974

romiplostim

Peptide

true

FDA (2008), EMA (2009)

178,103,553

309

catalytic_receptor

Prolactin receptor family

1,722

Thrombopoietin receptor

13,436

Agonist

null

-

5,063

thrombopoietin

Peptide

false

null

178,101,756

333

catalytic_receptor

Receptor tyrosine phosphatase (RTP) family

1,851

RTP Type B

82,785

Inhibitor

Inhibition

false

7.15

pIC50

8,786

compound 13e [PMID: 16759857]

Synthetic organic

false

null

252,827,444

333

catalytic_receptor

Receptor tyrosine phosphatase (RTP) family

1,851

RTP Type B

87,728

Inhibitor

Inhibition

false

6.15

pIC50

11,336

razuprotafib

Synthetic organic

false

null

440,816,705

333

catalytic_receptor

Receptor tyrosine phosphatase (RTP) family

1,853

RTP Type D

85,643

Inhibitor

Inhibition

true

null

pIC50

10,109

7-BIA

Synthetic organic

false

null

381,118,819

333

catalytic_receptor

Receptor tyrosine phosphatase (RTP) family

1,855

RTP Type F

82,742

Inhibitor

Inhibition

false

5.89

pIC50

8,770

illudalic acid

Synthetic organic

false

null

252,827,428

333

catalytic_receptor

Receptor tyrosine phosphatase (RTP) family

1,856

RTP Type G

82,872

Inhibitor

Inhibition

false

5.6

pKi

8,831

compound 1 [PMID: 21882820]

Synthetic organic

false

null

252,827,488

333

catalytic_receptor

Receptor tyrosine phosphatase (RTP) family

1,860

RTP Type M

82,925

Inhibitor

Inhibition

false

5.15

pIC50

8,856

compound 8a [PMID: 23713581]

Synthetic organic

false

null

252,827,513

333

catalytic_receptor

Receptor tyrosine phosphatase (RTP) family

1,866

RTP Type S

85,644

Inhibitor

Inhibition

false

4.4

pIC50

10,109

7-BIA

Synthetic organic

false

null

381,118,819

333

catalytic_receptor

Receptor tyrosine phosphatase (RTP) family

1,866

RTP Type S

82,915

Inhibitor

Inhibition

false

5.44

pIC50

8,850

compound 7b [Haftchenary <i>et al.</i>, 2013]

Synthetic organic

false

null

252,827,507

940

catalytic_receptor

RIG-I-like receptor family

2,920

DExD/H-box helicase 58

88,378

Agonist

false

null

-

11,795

SLR14

Synthetic organic

false

null

458,923,830

797

catalytic_receptor

RSTK functional heteromers

2,588

Activin receptors

79,955

Agonist

false

null

-

4,857

activin A

Peptide

false

null

178,101,558

797

catalytic_receptor

RSTK functional heteromers

2,588

Activin receptors

79,958

Agonist

false

null

-

4,858

activin AB

Peptide

false

null

178,101,559

797

catalytic_receptor

RSTK functional heteromers

2,588

Activin receptors

79,956

Agonist

false

null

-

4,859

activin B

Peptide

false

null

178,101,560

797

catalytic_receptor

RSTK functional heteromers

2,588

Activin receptors

79,957

Agonist

false

null

-

5,010

inhibin A

Peptide

false

null

178,101,707

797

catalytic_receptor

RSTK functional heteromers

2,589

Anti-Müllerian hormone receptors

78,668

Agonist

null

-

6,686

Müllerian inhibiting substance

Peptide

false

null

178,103,298

797

catalytic_receptor

RSTK functional heteromers

2,586

Bone morphogenetic protein receptors

78,661

Agonist

null

-

4,875

BMP-10

Peptide

false

null

178,101,575

797

catalytic_receptor

RSTK functional heteromers

2,586

Bone morphogenetic protein receptors

78,653

Agonist

null

-

4,881

BMP-2

Peptide

false

null

178,101,581

797

catalytic_receptor

RSTK functional heteromers

2,586

Bone morphogenetic protein receptors

78,654

Agonist

null

-

4,883

BMP-4

Peptide

false

null

178,101,583

797

catalytic_receptor

RSTK functional heteromers

2,586

Bone morphogenetic protein receptors

78,655

Agonist

null

-

4,884

BMP-5

Peptide

false

null

178,101,584

797

catalytic_receptor

RSTK functional heteromers

2,586

Bone morphogenetic protein receptors

78,656

Agonist

null

-

4,885

BMP-6

Peptide

false

null

178,101,585

797

catalytic_receptor

RSTK functional heteromers

2,586

Bone morphogenetic protein receptors

78,657

Agonist

null

-

4,886

BMP-7

Peptide

false

null

178,101,586

797

catalytic_receptor

RSTK functional heteromers

2,586

Bone morphogenetic protein receptors

78,658

Agonist

null

-

4,887

BMP-8A

Peptide

false

null

178,101,587

797

catalytic_receptor

RSTK functional heteromers

2,586

Bone morphogenetic protein receptors

78,659

Agonist

null

-

4,888

BMP-8B

Peptide

false

null

178,101,588

797

catalytic_receptor

RSTK functional heteromers

2,586

Bone morphogenetic protein receptors

78,660

Agonist

null

-

4,889

BMP-9

Peptide

false

null

178,101,589

797

catalytic_receptor

RSTK functional heteromers

2,587

Growth/differentiation factor receptors

78,662

Agonist

null

-

4,936

growth/differentiation factor-1

Peptide

false

null

178,101,634

797

catalytic_receptor

RSTK functional heteromers

2,587

Growth/differentiation factor receptors

78,665

Agonist

null

-

4,937

growth/differentiation factor-10

Peptide

false

null

178,101,635

797

catalytic_receptor

RSTK functional heteromers

2,587

Growth/differentiation factor receptors

78,663

Agonist

null

-

4,938

growth/differentiation factor-3

Peptide

false

null

178,101,636

797

catalytic_receptor

RSTK functional heteromers

2,587

Growth/differentiation factor receptors

81,905

Agonist

false

null

-

4,877

growth/differentiation factor-7

Peptide

false

null

178,101,577

797

catalytic_receptor

RSTK functional heteromers

2,587

Growth/differentiation factor receptors

78,664

Agonist

null

-

4,939

growth/differentiation factor-9

Peptide

false

null

178,101,637

797

catalytic_receptor

RSTK functional heteromers

2,585

Transforming growth factor β receptor

78,650

Agonist

null

-

5,060

TGFβ1

Peptide

false

null

178,101,753

797

catalytic_receptor

RSTK functional heteromers

2,585

Transforming growth factor β receptor

78,651

Agonist

null

-

5,061

TGFβ2

Peptide

false

null

178,101,754

797

catalytic_receptor

RSTK functional heteromers

2,585

Transforming growth factor β receptor

78,652

Agonist

null

-

5,062

TGFβ3

Peptide

false

null

178,101,755

316

catalytic_receptor

Toll-like receptor family

1,752

TLR2

83,029

Agonist

false

7.6

pKi

8,888

compound 13 [PMID: 23098072]

Synthetic organic

false

null

310,264,669

316

catalytic_receptor

Toll-like receptor family

1,752

TLR2

83,394

Agonist

false

null

-

9,024

defoslimod

Synthetic organic

false

null

315,661,109

316

catalytic_receptor

Toll-like receptor family

1,752

TLR2

86,260

Agonist

false

9.96

pEC50

10,341

diprovocim-1

Synthetic organic

false

null

381,745,022

316

catalytic_receptor

Toll-like receptor family

1,752

TLR2

13,464

Agonist

null

-

5,044

peptidoglycan

Natural product

false

null

178,101,739

316

catalytic_receptor

Toll-like receptor family

1,752

TLR2

84,052

Antibody

Binding

false

7.92

pKd

9,408

tomaralimab

Antibody

false

null

328,083,510

316

catalytic_receptor

Toll-like receptor family

1,752

TLR2

84,051

Antibody

Binding

true

7.54

pKd

9,408

tomaralimab

Antibody

false

null

328,083,510

316

catalytic_receptor

Toll-like receptor family

1,753

TLR3

13,465

Agonist

null

-

5,047

poly(I:C)

Synthetic organic

false

null

178,101,742

316

catalytic_receptor

Toll-like receptor family

1,754

TLR4

85,558

Agonist

Partial agonist

false

null

-

10,091

CRX-555

Synthetic organic

false

null

381,118,801

316

catalytic_receptor

Toll-like receptor family

1,754

TLR4

83,395

Agonist

false

null

-

9,024

defoslimod

Synthetic organic

false

null

315,661,109

316

catalytic_receptor

Toll-like receptor family

1,754

TLR4

87,398

Agonist

false

9.77

pEC50

11,150

GSK1795091

Synthetic organic

false

null

434,122,210

316

catalytic_receptor

Toll-like receptor family

1,754

TLR4

13,466

Agonist

null

-

5,019

LPS

Natural product

false

null

178,101,716

316

catalytic_receptor

Toll-like receptor family

1,754

TLR4

84,390

Agonist

false

null

-

9,137

neoceptin-3

Synthetic organic

false

null

315,661,222

316

catalytic_receptor

Toll-like receptor family

1,754

TLR4

13,467

Agonist

false

null

-

2,770

paclitaxel

Natural product

true

FDA (1992), EMA (2008)

135,652,721

316

catalytic_receptor

Toll-like receptor family

1,754

TLR4

83,405

Antagonist

true

null

-

9,036

resatorvid

Synthetic organic

false

null

315,661,121

316

catalytic_receptor

Toll-like receptor family

1,755

TLR5

13,468

Agonist

false

null

-

4,931

flagellin

Natural product

false

null

178,101,629

316

catalytic_receptor

Toll-like receptor family

1,757

TLR7

83,397

Agonist

false

5.21

pEC50

9,025

852A

Synthetic organic

false

null

315,661,110

316

catalytic_receptor

Toll-like receptor family

1,757

TLR7

83,396

Agonist

false

5.58

pEC50

9,025

852A

Synthetic organic

false

null

315,661,110

316

catalytic_receptor

Toll-like receptor family

1,757

TLR7

86,594

Antagonist

false

5.09

pIC50

10,435

compound 10a [PMID: 31283223]

Synthetic organic

false

null

385,612,195

316

catalytic_receptor

Toll-like receptor family

1,757

TLR7

88,657

Agonist

false

3.42

pEC50

11,977

compound 27 [WO2019226977A1]

Synthetic organic

false

null

464,244,118

316

catalytic_receptor

Toll-like receptor family

1,757

TLR7

87,657

Antagonist

false

6

pIC50

11,307

enpatoran

Synthetic organic

false

null

434,321,742

316

catalytic_receptor

Toll-like receptor family

1,757

TLR7

83,732

Agonist

true

null

-

9,254

GSK2245035

Synthetic organic

false

null

315,661,329

316

catalytic_receptor

Toll-like receptor family

1,757

TLR7

79,583

Antagonist

true

5.56

pIC50

7,198

hydroxychloroquine

Synthetic organic

true

FDA (1955)

178,103,773

316

catalytic_receptor

Toll-like receptor family

1,757

TLR7

13,470

Agonist

true

4.94

pEC50

5,003

imiquimod

Synthetic organic

true

FDA (1997), EMA (1998)

178,101,700

316

catalytic_receptor

Toll-like receptor family

1,757

TLR7

13,471

Agonist

null

-

5,018

loxoribine

Synthetic organic

false

null

178,101,715

316

catalytic_receptor

Toll-like receptor family

1,757

TLR7

13,469

Agonist

false

5.87

pEC50

5,051

resiquimod

Synthetic organic

false

null

178,101,746

316

catalytic_receptor

Toll-like receptor family

1,758

TLR8

83,750

Agonist

true

5.88

pEC50

9,270

3M-002

Synthetic organic

false

null

315,661,345

316

catalytic_receptor

Toll-like receptor family

1,758

TLR8

84,634

Agonist

true

5.3

pEC50

9,690

compound 12p [Larson <i>et al.</i>, 2017]

Synthetic organic

false

null

348,353,649

316

catalytic_receptor

Toll-like receptor family

1,758

TLR8

88,668

Antagonist

false

8.7

pIC50

11,989

compound 15 [PMID: 35450354]

Synthetic organic

false

null

464,244,130

316

catalytic_receptor

Toll-like receptor family

1,758

TLR8

84,826

Inhibitor

Inhibition

false

6.66

pKd

9,795

CU-CPT8m

Synthetic organic

false

null

354,702,267

316

catalytic_receptor

Toll-like receptor family

1,758

TLR8

84,825

Inhibitor

Inhibition

false

7.17

pIC50

9,795

CU-CPT8m

Synthetic organic

false

null

354,702,267

316

catalytic_receptor

Toll-like receptor family

1,758

TLR8

83,398

Agonist

false

7

pEC50

9,026

motolimod

Synthetic organic

false

null

315,661,111