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RAG Datasets 12

What is the target of Sotorasib?

Sotorasib is a KRASG12C inhibitor.

[33097477, 34553354, 34504076, 33547148, 34800654, 34004237, 34675734, 32955176, 33004338, 34838325, 34558391, 34715449, 34776511, 34137282, 34158284, 34607832, 34607583, 34200676, 34590053, 33466360, 33971321, 34520956]

Is ASF1 phopshorylated by the Tousled-like kinases?

Yes, Asf1, a key histone H3-H4 chaperone required for this process, is phosphorylated by Tousled-like kinases (TLKs).

[24598821, 23869254, 20222959, 23946870, 32755577]

What is Luteolin?

Luteolin has been reviewed as a flavonoid possessing potential cardioprotective, anti-inflammatory, anti-cancer activities.

[27016074, 32081041, 21881237, 16140950, 24477342, 12027807, 24353826, 26020516, 29207088, 28282295, 10972088, 27170112, 34717250, 31994822, 30119240, 27185356, 18937165, 29928143, 23317200, 18991571, 26246742, 31019613, 22203870, 20074346, 22269172, 32407927, 34460026, 32694396, 33469821, 30280574]

Does sphingosine-1 phosphoate suppress epiregulin?

Sphingosine-1 phosphate induces epiregulin (EREG) gene expression.

[33189864]

Which is the literature-based database of phenotypes?

PheneBank is a Web-portal for retrieving human phenotype-disease associations that have been text-mined from the whole of Medline. This approach exploits state-of-the-art machine learning for concept identification by utilising an expert annotated rare disease corpus from the PMC Text Mining subset. Evaluation of the system for entities is conducted on a gold-standard corpus of rare disease sentences and for associations against the Monarch initiative data.

[34788791]

Idecabtagene vicleucel can be used for treatment of which disease?

Idecabtagene vicleucel was shown to be effective for Relapsed and Refractory Multiple Myeloma.

[33598857, 34145225, 33626253, 34625232, 34854741, 34527606, 34461271, 33896344, 34104374, 34256668]

LINC00339 is a diagnostic, prognostic and treatment efficacy biomarker for what disease?

LINC00339 as a cancer diagnostic, prognostic and treatment efficacy biomarker.

[32991297, 34741346, 31188482, 31239716, 30618083, 33235461, 30485513, 32308105, 28171565, 31269584, 31081143, 31781497, 29499931, 29906749, 31128030, 34105151]

What is the role of PCAT6 in human cancers?

PCAT6, is a carcinogenic lncRNA. It is abnormally elevated in various human malignant tumors. PCAT6 has been found to sponge various miRNAs to activate the signaling pathways, which further affects tumor cell proliferation, migration, invasion, cycle, apoptosis, radioresistance, and chemoresistance. It is believed to have diagnostic and prognostic value and clinical applications in various human malignancies.

[34885209, 31676070]

Can whole genome sequencing be used for diagnosis of mitochondrial disease?

Yes. Whole genome sequencing is a useful diagnostic test in patients with suspected mitochondrial disorders, yielding a diagnosis in a further 31% after exclusion of common causes. Most diagnoses were non-mitochondrial disorders and included developmental disorders with intellectual disability, epileptic encephalopathies, other metabolic disorders, cardiomyopathies, and leukodystrophies. These would have been missed if a targeted approach was taken, and some have specific treatments.

[34732400]

What are the targets of avapritinib?

Avapritinib is a novel inhibitor of KIT/PDGFRA. It is approved in the U.S. for the treatment of adults with PDGFRA exon 18-mutant unresectable or metastatic gastrointestinal stromal tumors.

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What is Jackhammer esophagus?

Jackhammer esophagus (JE) is a hypercontractile esophageal motor disorder defined by at least two swallows with a distal contractile integral (DCI) >8000 mm Hg.s.cm during high-resolution manometry (HRM).

[34642274, 27458179, 33043556, 33337637, 34001027, 30543463, 26927491, 27274539, 30941328, 32601779, 27660053, 23452629, 29667413, 25961439, 32510747, 29967357, 29521727]

Can METTL3 methylate long noncoding RNAs?

Yes, METTL3 can modulate methylation and expression of lncRNA.

[34505967]

Which disease is caused by repeat expansion in VWA1?

An ancestral 10-bp repeat expansion in VWA1 causes recessive hereditary motor neuropathy.

[33559681]

What is the use of the Apfel Score?

The Apfel simplified risk score, developed in 1999, is the most widely used tool for risk stratification of postoperative nausea and vomiting.

[33832577, 27902493, 34041090, 34782501, 33250474, 33721198, 32415631, 31230771, 11861340, 17236637, 33683710, 34067551]

Is PPROM a condition that occurs in males or females?

Preterm premature rupture of fetal membranes (PPROM) occurs in pregnant females.

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What is EpiMethylTag?

EpiMethylTag is a fast, low-input, low sequencing depth method, that combines ATAC-seq or ChIP-seq (M-ATAC or M-ChIP) with bisulfite conversion, to simultaneously examine accessibility/TF binding and methylation on the same DNA.

[31752933]

What is the target of Sutimlimab?

Sutimlimab is a novel humanized monoclonal antibody directed against classical pathway complement factor C1s.

[30635392, 31229501, 33826820, 32176765, 31114413, 31523413, 33512410, 30559259, 29737533, 34482398, 33261023]

Can parasite infections by Schistosoma japonicum prevent or improve asthma?

A peptide named as SJMHE1 from Schistosoma japonicum can suppress asthma in mice.

[26840774, 34703270, 28614408, 31496071, 18654798, 17042799, 34169075, 18824533, 34358648]

Describe Multilocus Inherited Neoplasia Allele Syndrome (MINAS)

Genetic testing of hereditary cancer using comprehensive gene panels can identify patients with more than one pathogenic mutation in high and/or moderate-risk-associated cancer genes. This phenomenon is known as multilocus inherited neoplasia alleles syndrome (MINAS), which has been potentially linked to more severe clinical manifestations.

[30580288]