Datasets:

yxchar

/

rct-20k-tlm

like 0

These results will serve as a benchmark to which we can compare future findings from the ongoing extended follow-up of participants in the Costa Rica trial .

Registered with clinicaltrials.gov : NCT00128661 .

There is a long-held concept among spine surgeons that endoscopic lumbar discectomy procedures are reserved for small-contained disc herniation ; 8-year follow-up has not been reported .

The purpose of this study is to assess microendoscopic discectomy ( MED ) in patients with large uncontained lumbar disc herniation ( the antero-posterior diameter of the extruded fragment is 6-12 mm or more on axial cuts of MRI ) and report long-term outcome .

One hundred eighty-five patients with MED or standard open discectomy underwent follow-up for 8 years .

Primary ( clinical ) outcomes data included Numerical Rating Scale ( NRS ) for back and leg symptoms and Oswestry Disability Index ( ODI ) to quantify pain and disability , respectively .

Secondary ( objective ) outcomes data included operative time , blood loss , postoperative analgesics , length of hospital stay , time to return to work , reoperation and complication rate , patient satisfaction index ( PSI ) , and modified ( MacNab ) criteria .

At the end of the follow-up , the leg pain relief was statistically significant for both groups .

NRS back pain , ODI , PSI and MacNab criteria showed significant deterioration for control group .

Secondary outcomes data of MED group were significantly better than the control group .

Large , uncontained , lumbar disc herniations can be sufficiently removed using MED which is an effective alternative to open discectomy procedures with remarkable long-term outcome .

Although the neurological outcome of the two procedures is the same , the morbidity of MED is significantly less than open discectomy .

Maximum benefit can be gained if we adhere to strict selection criteria .

The optimum indication is single - or multi-level radiculopathy secondary to a single-level , large , uncontained , lumbar disc herniation .

Heart failure ( HF ) patients suffer from frequent and repeated hospitalizations , causing a substantial economic burden on society .

Hospitalizations can be reduced considerably by better compliance with self-care .

Home telemonitoring has the potential to boost patients ' compliance with self-care , although the results are still contradictory .

A randomized controlled trial was conducted in order to study whether the multidisciplinary care of heart failure patients promoted with telemonitoring leads to decreased HF-related hospitalization .

HF patients were eligible whose left ventricular ejection fraction was lower than 35 % , NYHA functional class 2 , and who needed regular follow-up .

Patients in the telemonitoring group ( n = 47 ) measured their body weight , blood pressure , and pulse and answered symptom-related questions on a weekly basis , reporting their values to the heart failure nurse using a mobile phone app .

The heart failure nurse followed the status of patients weekly and if necessary contacted the patient .

The primary outcome was the number of HF-related hospital days .

Control patients ( n = 47 ) received multidisciplinary treatment according to standard practices .

Patients ' clinical status , use of health care resources , adherence , and user experience from the patients ' and the health care professionals ' perspective were studied .

Adherence , calculated as a proportion of weekly submitted self-measurements , was close to 90 % .

No difference was found in the number of HF-related hospital days ( incidence rate ratio [ IRR ] = 0.812 , P = .351 ) , which was the primary outcome .

The intervention group used more health care resources : they paid an increased number of visits to the nurse ( IRR = 1.73 , P < .001 ) , spent more time at the nurse reception ( mean difference of 48.7 minutes , P < .001 ) , and there was a greater number of telephone contacts between the nurse and intervention patients ( IRR = 3.82 , P < .001 for nurse-induced contacts and IRR = 1.63 , P = .049 for patient-induced contacts ) .

There were no statistically significant differences in patients ' clinical health status or in their self-care behavior .

The technology received excellent feedback from the patient and professional side with a high adherence rate throughout the study .

Home telemonitoring did not reduce the number of patients ' HF-related hospital days and did not improve the patients ' clinical condition .

Patients in the telemonitoring group contacted the Cardiology Outpatient Clinic more frequently , and on this way increased the use of health care resources .

Clinicaltrials.gov NCT01759368 ; http://clinicaltrials.gov/show/NCT01759368 ( Archived by WebCite at http://www.webcitation.org/6UFxiCk8Z ) .

Probiotics help maintain balance in composition of the gut microbiota , and have been considered as a potential treatment for obesity .

This study was conducted in order to assess the effects of probiotics when combined with herbal medicine in treatment of obesity .

Probiotics were tested for the ability to modulate gut microbiota , gut permeability , and endotoxin level , which may have correlation with factors involved in obesity .

A randomized , double-blind , placebo controlled study was conducted , in which patients with higher BMI ( > 25kg/m ( 2 ) ) and waist circumference ( > 85cm ) were enrolled and randomly assigned to receive Bofutsushosan with either probiotics or placebo capsules for a period of eight weeks .

Assessment of body composition parameters , metabolic biomarkers , endotoxin level , gut permeability , and fecal bacteria in stool was performed at baseline and at week 8 .

The study was registered at the Clinical Research Information Service , approved by the Korea National Institute of Health ( KCT0000386 ) .

Although both groups showed a significant reduction in weight and waist circumference ( p = 0.000 ) , no significant differences in body composition and metabolic markers were observed .

In correlation analysis , change in body composition showed positive correlation with endotoxin level ( r = 0.441 , p < 0.05 for BW ; and r = 0.350 , p < 0.05 for fat mass ) and the population of gut Lactobacillus plantarum ( r = 0.425 , p < 0.05 for BW ; and r = 0.407 , p < 0.05 for BMI ) .

The Gram negative bacterial population in gut also exhibited positive correlation with changes in body composition ( WC ) and total cholesterol level ( r = 0.359 , and 0.393 , for the former and later parameters , respectively , p < 0.05 for both ) .

While , the profile of gut Bifidobacterium breve population showed negative correlation with endotoxin level ( r = -0.350 , p < 0.05 ) .

Correlations between gut microbiota and change in body composition indicate that probiotics may influence energy metabolism in obesity .

Correlation between endotoxin level and weight reduction indicates that probiotics may play an important role in prevention of endotoxin production , which can lead to gut microbiota dysbiosis associated with obesity .

The objective of this study is to analyze the effects of a 12-week indoor intermittent training program on lung function , physical capacity , body composition and quality of life in children with asthma .

Participants were randomized in an experimental group ( EG , 58 children , age = 11.551.01 years ) and in a control group ( CG , 47 children , age = 11.511.42 years ) .

The training program was conducted indoors and consisted of alternating high - and low-intensity stimuli , for three sessions of 60min/week , for 12 weeks .

Physical exercise and sports activities were organized to follow the criteria of the American College of Sports Medicine ( 1999 ) and previous interventions ' studies .

In EG , there was a significant improvement ( p < 0.05 ) in FEV1 , FEV6 , 6MWT , handgrip strength , CMJ and flexibility .

Reductions in BMI and fat mass as well as an increase in quality of life were all shown .

The dyspnea index decreased significantly and there were no episodes of EIA .

There is a significant positive correlation ( p < 0.01 ) between the FEV1 with handgrip strength and 6MWT and a negative correlation with fat mass .

An indoor intermittent training program with these characteristics has improved lung function , physical capacity , body composition and quality of life in children with asthma .

These training adaptations are particularly relevant for those patients suffering from asthma as a regular physical exercise routine will greatly improve their quality of life .

To observe the efficacy of catgut implantation at back-shu points in treatment of mild perimenopausal depression of kidney , deficiency and liver stagnation syndrome and analyze its essential function on target symptoms .

Forty-five cases were randomized into a catgut implantation group ( 23 cases ) and atid acupuncture group ( 22 cases ) .

In the catgut implantation group , catguts were implanted at Shenshu ( BL 23 ) , Ganshu ( BL 18 ) , Xinshu ( BL 15 ) , Pishu ( BL 20 ) , etc. , once every week .

In the acupuncture group , the conventional acupuncture was applied to the same acupoints as the catgut implantation group , once every two days .

The : treatment of 4 weeks made one session , and continuous 2 sessions were required .

The efficacy was evaluated in , 2 sessions .

The follow-up started in the 12th week .

Before treatment , after treatment and in the follow-up period , Kupperman score and the total score in Hamilton depression scale ( HAMD ) , as well as the factor score were observed in the patients separately .

Kupperman score , the total HAMD score and the scores in the items of anxiety/somatization , retardation , sleep disorder and cognitive disorder after treatment were all reduced significantly as compared with those before treatment in the two groups ( P < 0.01 , P < 0.05 ) .

In the follow-up period , the difference in Kupperman was not significant in comparison with that after treatment in the catgut implantation : group ( P > 0.05 ) .

The total HAMD score and sleep disorder were reduced significantly as compared with those after treatment in the catgut implantation group ( both P < 0.01 ) ; in the acupuncture group , Kupperman score , the total HAMD score and sleep disorder were all increased as compared with those after treatment ( all P < 0.05 ) .

In ; the catgut implantation group , the total HAMD score was lower than that in the acupuncture group ( P < 0.05 ) , and the scores in the items of retardation and sleep disorder were reduced significantly as compared with those in the acupuncture group ( both P < 0.01 ) .

The catgut implantation at back-shu points alleviates perimenopasual sympton is in patients of mild perimenopausal depression of kidney deficiency and liver stagnation syndrome .

This therapy effectively relieves depressive disorders by regulating the target symptoms such as anxiety / somatization , retardation , sleep disorder and cognitive ' disorder .

The long-term efficacy of this therapy is better than the conventional acupuncture .

Up to 25 % of patients who undergo a percutaneous coronary intervention show some limitation in the use of drug-eluting stents .

The aim of this study was to evaluate if titanium-nitride-oxide-coated stents could be a good alternative to everolimus-eluting stents in diabetic patients .

A total of 173 diabetic patients with lesions at moderate risk of restenosis ( exclusion criteria : diameter < 2.5 mm or length > 28 mm in vessels < 3mm , chronic occlusion ) were randomized to a titanium group ( 83 patients ) or an everolimus group ( 90 patients ) .

Baseline characteristics were well balanced ; 28.3 % of patients were insulin dependent .

At 1 year , the incidence of major adverse cardiac events ( death , nonfatal myocardial infarction , stroke , or repeat target vessel revascularization ) was significantly higher in the titanium group than in the everolimus group ( total , 14.5 % vs 4.4 % ; P = .02 ; noninsulin-dependent subgroup , 9.7 % vs 3.2 % ; P = .14 ; insulin-dependent subgroup , 28.6 % vs 7.1 % ; P = .04 ) .

The incidence of death , nonfatal myocardial infarction , stroke , or any revascularization was 16.9 % in the titanium group and 7.8 % in the everolimus group ( P = .06 ) .

Target lesion and vessel revascularizations occurred in 8.4 % compared with 3.3 % ( P = .15 ) and in 13.3 % compared with 3.3 % ( P = .01 ) in the titanium and everolimus groups , respectively .

Angiographic follow-up at 9 months showed significantly less late lumen loss in the everolimus group ( in-segment , 0.52 [ standard deviation , 0.58 ) mm vs -0.05 [ 0.32 ] mm ; in-stent , 0.76 [ 0.54 ] mm vs 0.13 [ 0.31 ] mm ; P < .0001 ) .

The everolimus-eluting stent is superior to the titanium stent for clinical and angiographic end points in diabetic patients with lesions at moderate risk of restenosis .

To evaluate the safety of the fixed combination of ibuprofen and famotidine compared with ibuprofen alone from two 24-week , multicenter , double-blind trials designed to evaluate the comparative incidence of endoscopically documented upper gastrointestinal ulcers and a 28-week double-blind extension study .

Safety was analyzed by pooling data from the two double-blind trials and the follow-on study .

Safety was assessed by monitoring the incidence , causality , and severity of adverse events ( AEs ) .

In the pivotal efficacy and safety trials , discontinuation rates due to any cause and dyspepsia were significantly lower for the ibuprofen/famotidine combination versus ibuprofen alone .

Other than dyspepsia , gastrointestinal and cardiovascular AEs of special interest were similar .

Events judged to be treatment related were significantly lower with the ibuprofen/famotidine combination ( 20.6 % vs. 25 % ) .

In the safety extension population , there were no differences in the discontinuation rates and the reporting of AEs or serious AEs ( SAEs ) between the two groups .

Gastrointestinal-related events were similar between the groups .

Incidence of cardiovascular-related AEs of special interest were 11 % ( ibuprofen/famotidine ) and 2 % ( ibuprofen ) ( p = 0.06 ) , possibly due to a higher number of rheumatoid arthritis patients in the combination group .

Of these , 80 % were reports of hypertension ( 8 % ibuprofen/famotidine vs. 2 % ibuprofen ) .

Three cases of hypertension in the ibuprofen/famotidine group were considered treatment related .

The probability of a cardiovascular event decreased during days 112-167 of treatment and remained low with continued treatment .

One-year safety data from two pivotal trials and a long-term extension study indicate that the ibuprofen/famotidine combination demonstrates a favorable gastrointestinal safety profile and more patients continued on therapy compared to ibuprofen alone .

No new safety signals have been identified .

These data offer additional evidence supporting a new therapeutic option to improve gastrointestinal safety and adherence for patients who require long-term ibuprofen .

To compare the effects of volume-controlled ventilation ( VCV ) and pressure-controlled volume-guaranteed ( PCV-VG ) mode during one-lung ventilation ( OLV ) on circulation , pulmonary function and lung injury .

2012 February to 2013 March in Ningbo No2 .

Hospital cardiothoracic surgery , 30 patients aged 52 to 76 years ( ASA grade II-III ) undergoing elective thoracoscopic lobectomy were randomly divided into VCV group and PCV-VG group , with 15 cases in each group .

After anesthesia induction and endotracheal intubation , endobronchial blocker was inserted to start OLV .

Heart rate ( HR ) , mean arterial pressure ( MAP ) , measured tidal volume ( TV ) , peak airway pressure ( Ppeak ) , airway resistance ( Raw ) , chest compliance ( Cdyn ) and the end-tidal carbon dioxide pressure ( PetCO ( 2 ) ) were recorded at the time point of 15 minutes after turning to the lateral position , 15 minutes and 60 minutes after OLV , and 15 minutes after the resumption of two lung ventilation .

In the meanwhile , arterial blood gas analysis was conducted to measure indicators of pH , oxygen tension ( PaO ( 2 ) ) and carbon dioxide partial pressure ( PaCO ( 2 ) ) .

Blood was drawn before induction , 1 hour after OLV and 1 hour after the end of surgery , and the concentration of interleukin-6 ( IL-6 ) and tumor necrosis factor-alpha ( TNF - ) were detected by enzyme-linked immunosorbent assay ( ELISA ) .